Prevalence of diabetic ketoacidosis in newly diagnosed children and adolescents with type 1 diabetes mellitus. Experience of a center for pediatric diabetology in Germany
Prevalence of diabetic ketoacidosis in newly diagnosed children and adolescents with type 1 diabetes mellitus. Experience of a center for pediatric diabetology in Germany
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DOI：
10.1007/s001120170122
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发表时间：
2001-07-01
影响因子：
0.4
通讯作者：
Kiess, W
中科院分区：
文献类型：
--
作者：
Kapellen, TM;Galler, A;Kiess, W
导论.糖尿病酮症酸中毒（diabetic ketoacidosis，DKA）是新诊断的1型糖尿病患儿最严重的并发症，也是脑水肿导致死亡的最常见原因。方法回顾性分析1995 ~ 1999年莱比锡大学儿童医院新诊断的1型糖尿病患儿的临床资料。31例患者（29.8%）发生DKA，其中10例无意识或嗜睡。DKA儿童和青少年的血糖水平、糖化血红蛋白水平和初始胰岛素需求较高，住院时间较长。DKA组的缓解率较低（67 vs. 80.8%）。14%的无DKA患者报告延迟或误诊，但22.5%的儿童和青少年DKA患者报告延迟或误诊。为了提高糖尿病的缓解率并减少糖尿病发作时的住院时间，必须降低DKA的发生率，因为在一般人群中，特别是在全科医生和儿科医生中，有更好的糖尿病症状信息。
Introduction. Diabetic ketoacidosis (DKA) is still the most serious complication of the newly diagnosed child with diabetes mellitus type 1 because it is still the most common cause of death due to cerebral edema.Methods. All patient records of children with new diagnosed type 1 diabetes mellitus in the children's hospital of the University of Leipzig in 1995 to 1999 were analysed retrospectively.Results. 31 patients (29,8%) had DKA, 10 of which were unconscious or somnolent. In those children and adolescents with DKA blood glucose levels, glycosylated hemoglobin levels and initial insulin requirement were higher and the duration of hospital stay was longer. The rate of remission was lower in the DKA group (67 vs. 80.8%). A delayed or false diagnosis was reported in 14% of patients without but in 22,5% of the children and adolescents with DKA.Conclusion. To improve the rate of remission and reduce the hospital stay at the onset of diabetes mellitus the rate of DKA must be reduced due to better information about symptoms of diabetes mellitus in the general population and especially among general practitioners and pediatricians.