Helicobacter pylori infection and inflammatory bowel disease: a crosstalk between upper and lower digestive tract.
Helicobacter pylori infection and inflammatory bowel disease: a crosstalk between upper and lower digestive tract.
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幽门螺杆菌感染和炎症性肠病：上消化道和下消化道之间的串扰。
DOI：
10.1038/s41419-018-0982-2
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发表时间：
2018-09-20
影响因子：
9
通讯作者：
Zhang S
中科院分区：
文献类型：
--
作者：
Yu Y;Zhu S;Li P;Min L;Zhang S
幽门螺杆菌已经与人类共存了大约60，000年，全球超过50%的人口感染了幽门螺杆菌。幽门。H. pylori的体外培养获得成功，在过去的35年里，幽门螺杆菌已经取得了实质性的进展。此后，H。幽门螺杆菌是慢性胃炎、消化性溃疡和胃恶性肿瘤的主要致病因素。许多患者接受了H。pylori根除治疗，但只有1-2%的H.幽门感染的个体最终发展成胃癌。近年来，大量的流行病学和基础实验研究表明，慢性H。幽门螺杆菌感染通过诱导系统性免疫耐受和抑制炎症反应来预防炎症性肠病（IBD）。本文就近年来有关H. pylori与IBD的关系，并进一步阐述了H.幽门螺杆菌诱导的具有致耐受表型的树突状细胞（DC）和免疫抑制调节性T细胞（TCLs）。基于H. pylori感染对IBD的影响，提示H. pylori与宿主关系复杂，H.幽门螺杆菌根除治疗应谨慎，尤其是对儿童和年轻人。
Helicobacter pylori has coexisted with humans for approximately 60,000 years and greater than 50% of the global population is infected with H. pylori. H. pylori was successfully cultured in vitro in 1983 and studies of H. pylori have achieved substantial advances over the last 35 years. Since then, H. pylori has been characterized as the primary pathogenic factor for chronic gastritis, peptic ulcer, and gastric malignancy. Numerous patients have received H. pylori eradication treatment, but only 1–2% of H. pylori-infected individuals ultimately develop gastric cancer. Recently, numerous epidemiological and basic experimental studies suggested a role for chronic H. pylori infection in protecting against inflammatory bowel disease (IBD) by inducing systematic immune tolerance and suppressing inflammatory responses. Here we summarize the current research progress on the association between H. pylori and IBD, and further describe the detailed molecular mechanism underlying H. pylori-induced dendritic cells (DCs) with the tolerogenic phenotype and immunosuppressive regulatory T cells (Tregs). Based on the potential protective role of H. pylori infection on IBD, we suggest that the interaction between H. pylori and the host is complicated, and H. pylori eradication treatment should be administered with caution, especially for children and young adults.
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影响因子：
9.8
作者：
Begue, Bernadette;Verdier, Julien;Ruemmele, Frank M.
通讯作者：
Ruemmele, Frank M.
影响因子：
4.4
作者：
Hitzler, Iris;Sayi, Ayca;Mueller, Anne
通讯作者：
Mueller, Anne
影响因子：
4.9
作者：
Baumgart, Daniel C.;Bernstein, Charles N.;Yamamoto-Furusho, Jesus K.
通讯作者：
Yamamoto-Furusho, Jesus K.
DOI：
10.1084/jem.20111453
发表时间：
2012-08-27
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Coccia M;Harrison OJ;Schiering C;Asquith MJ;Becher B;Powrie F;Maloy KJ
通讯作者：
Maloy KJ
DOI：
10.1073/pnas.1410579111
发表时间：
2014-08-12
影响因子：
11.1
作者：
Engler, Daniela B.;Reuter, Sebastian;Mueller, Anne
通讯作者：
Mueller, Anne