Right lateralized white matter abnormalities in first-episode, drug-naive paranoid schizophrenia
Right lateralized white matter abnormalities in first-episode, drug-naive paranoid schizophrenia
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首发、未用药偏执型精神分裂症患者右侧白质异常
DOI：
10.1016/j.neulet.2012.09.033
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发表时间：
2012-11-30
影响因子：
2.5
通讯作者：
Zhao, Jingping
中科院分区：
文献类型：
--
作者：
Guo, Wenbin;Liu, Feng;Zhao, Jingping
对首发精神分裂症的大量研究表明，多个区域的白质 (WM) 异常参与了这种疾病的发病机制。然而，目前还没有使用基于束的空间统计（TBSS）方法对首发、未曾用药的偏执型精神分裂症患者进行神经影像学研究。在这里，我们使用弥散张量成像 (DTI) 和 TBSS 方法来研究首发药物偏执型精神分裂症患者的大脑 WM 完整性。对 20 名初治偏执型精神分裂症首发患者和 26 名年龄、性别和教育水平相匹配的健康受试者进行了 DTI 扫描。采用自动化 TBSS 方法来分析数据。体素统计显示，与健康受试者相比，偏执型精神分裂症患者的右上纵束 (SLF) II、右侧穹窿、右侧内囊和右侧外囊的分数各向异性 (FA) 值降低。与健康受试者相比，患者任何大脑区域的 FA 值均没有增加。任何大脑区域的 FA 值与患者人口统计数据和疾病严重程度之间没有相关性。我们的研究结果表明，皮质和皮质下区域的 WM 束中 WM 完整性的右侧改变可能在偏执型精神分裂症的发病机制中发挥重要作用。 (C) 2012 Elsevier Ireland Ltd. 保留所有权利。
Numerous studies in first-episode schizophrenia suggest the involvement of white matter (WM) abnormalities in multiple regions underlying the pathogenesis of this condition. However, there has never been a neuroimaging study in patients with first-episode, drug-naive paranoid schizophrenia by using tract-based spatial statistics (TBSS) method. Here, we used diffusion tensor imaging (DTI) with TBSS method to investigate the brain WM integrity in patients with first-episode, drug-naive paranoid schizophrenia. Twenty patients with first-episode, drug-naive paranoid schizophrenia and 26 healthy subjects matched with age, gender, and education level were scanned with DTI. An automated TBSS approach was employed to analyze the data. Voxel-wise statistics revealed that patients with paranoid schizophrenia had decreased fractional anisotropy (FA) values in the right superior longitudinal fasciculus (SLF) II, the right fornix, the right internal capsule, and the right external capsule compared to healthy subjects. Patients did not have increased FA values in any brain regions compared to healthy subjects. There was no correlation between the FA values in any brain regions and patient demographics and the severity of illness. Our findings suggest right-sided alterations of WM integrity in the WM tracts of cortical and subcortical regions may play an important role in the pathogenesis of paranoid schizophrenia. (C) 2012 Elsevier Ireland Ltd. All rights reserved.