EXPERIMENTAL-STUDY OF THE REGENERATIVE POTENTIAL OF PERINEURIUM AT A SITE OF NERVE TRANSECTION
EXPERIMENTAL-STUDY OF THE REGENERATIVE POTENTIAL OF PERINEURIUM AT A SITE OF NERVE TRANSECTION
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DOI：
10.3171/jns.1981.54.1.0079
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发表时间：
1981-01-01
影响因子：
4.1
通讯作者：
ACLAND, RD
中科院分区：
文献类型：
--
作者：
BEHRMAN, JE;ACLAND, RD
在一系列大鼠中横切单个坐骨神经束。通过三种实验模型中的一种修复神经：未修剪的凸出轴突的神经束膜缝合、修剪的凸出轴突的神经束膜缝合以及神经束膜缝合以产生错位的束。在0-42天时切除神经并进行薄的纵向切片检查。在所有时间间隔和所有模型中都观察到完全没有神经周围再生。束内轴突的再生紊乱。轴突再生延伸到周围的结缔组织并浸润近端和远端神经束膜。
A single fascicle of sciatic nerve was transected in a series of rats. The nerve was repaired by 1 of 3 experimental models: perineurial suturing with bulging axons untrimmed, perineurial suturing with bulging axons trimmed and perineurial suturing to produce a misaligned fascicle. Nerves were excised at 0-42 days and were examined in thin, longitudinal section. The complete absence of perineurial regeneration was observed at all time intervals and in all models. Regeneration of axons within the fascicle was disordered. Axonal regeneration extended into the surrounding connective tissue and infiltrated both the proximal and distal perineurium.