UV-Induced TA Photoproducts: Formation and Hydrolysis in Double-Stranded DNA

UV-Induced TA Photoproducts: Formation and Hydrolysis in Double-Stranded DNA
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DOI:
10.1021/ja1023173
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发表时间:
2010-08-04
影响因子:
15
通讯作者:
Clivio, Pascale
Clivio, Pascale
中科院分区:
化学1区
文献类型:
--
作者:
Asgatay, Saadia;Martinez, Agathe;Clivio, Pascale

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TA光产物的水解导致两种衍生物呈现不同的形成动力学曲线,这取决于低聚物含量。在UV-C照射的DNA中TA光产物的形成效率略微超过在TT位点处反式,顺式环丁烷嘧啶二聚体的形成。
Hydrolysis of TA photoproduct leads to two derivatives presenting different formation kinetic profiles depending on the oligomer content. The formation efficiency of TA photoproducts in UV-C-irradiated DNA slightly exceeds the formation of the trans,syn cyclobutane pyrimidine dimer at TT sites.