Hemocompatibility of styrenic block copolymers for use in prosthetic heart valves.
Hemocompatibility of styrenic block copolymers for use in prosthetic heart valves.
复制标题
用于假体心脏瓣膜中使用的苯乙烯块共聚物的血流相容性。
DOI：
10.1007/s10856-015-5628-7
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发表时间：
2016-02
期刊：
影响因子：
--
通讯作者：
Moggridge GD
中科院分区：
文献类型：
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作者：
Brubert J;Krajewski S;Wendel HP;Nair S;Stasiak J;Moggridge GD
某些苯乙烯类热塑性嵌段共聚物弹性体可以加工成表现出各向异性的机械性能，这可能是模仿生物组织所需要的。采用改良钱德勒环法，利用新鲜人血和成纤维细胞在材料上的直接接触增殖，测试了聚苯乙烯硬块与聚乙烯、聚丙烯、聚异戊二烯、聚丁二烯或聚异丁烯软块组成的四种三嵌段（硬-软-硬）共聚物的体外血液相容性。并对肝素涂层的血液相容性和耐久性进行了评价。血小板和凝血级联激活的测量表明，测试材料优于聚酯，但低于膨胀聚四氟乙烯和牛心包标准材料。抗炎措施测试材料优于聚酯和牛心包。肝素涂层的添加导致蛋白质吸附减少，体外血液相容性优于所有标准材料，在所有措施。经测试的苯乙烯热塑性嵌段共聚物在血液接触应用中表现出足够的性能。
Certain styrenic thermoplastic block copolymer elastomers can be processed to exhibit anisotropic mechanical properties which may be desirable for imitating biological tissues. The ex-vivo hemocompatibility of four triblock (hard–soft–hard) copolymers with polystyrene hard blocks and polyethylene, polypropylene, polyisoprene, polybutadiene or polyisobutylene soft blocks are tested using the modified Chandler loop method using fresh human blood and direct contact cell proliferation of fibroblasts upon the materials. The hemocompatibility and durability performance of a heparin coating is also evaluated. Measures of platelet and coagulation cascade activation indicate that the test materials are superior to polyester but inferior to expanded polytetrafluoroethylene and bovine pericardium reference materials. Against inflammatory measures the test materials are superior to polyester and bovine pericardium. The addition of a heparin coating results in reduced protein adsorption and ex-vivo hemocompatibility performance superior to all reference materials, in all measures. The tested styrenic thermoplastic block copolymers demonstrate adequate performance for blood contacting applications.