The Use of Induced Pluripotent Stem Cells in Drug Development
The Use of Induced Pluripotent Stem Cells in Drug Development
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DOI：
10.1038/clpt.2011.38
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发表时间：
2011-05-01
影响因子：
6.7
通讯作者：
Yamanaka, S.
中科院分区：
文献类型：
--
作者：
Inoue, H.;Yamanaka, S.
诱导多能干细胞（iPSC）技术正在彻底改变医学科学，允许探索疾病机制和新的治疗分子靶点，并为药物开发中的药物发现和概念验证研究提供机会。本文综述了iPSC技术的最新进展，包括其分析范式中的疾病建模和控制设置。我们描述了iPSC技术如何整合到现有的药物开发范式中，并讨论了iPSC技术在个性化医疗中的潜力。
Induced pluripotent stem cell (iPSC) technology is revolutionizing medical science, allowing the exploration of disease mechanisms and novel therapeutic molecular targets, and offering opportunities for drug discovery and proof-of-concept studies in drug development. This review focuses on the recent advancements in iPSC technology including disease modeling and control setting in its analytical paradigm. We describe how iPSC technology is integrated into existing paradigms of drug development and discuss the potential of iPSC technology in personalized medicine.