Validating a Sham Condition for Use in High Definition Transcranial Direct Current Stimulation
Validating a Sham Condition for Use in High Definition Transcranial Direct Current Stimulation
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DOI：
10.1016/j.brs.2015.01.399
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发表时间：
2015-05-01
影响因子：
7.7
通讯作者：
den Ouden, Dirk-Bart
中科院分区：
文献类型：
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作者：
Garnett, Emily O.;den Ouden, Dirk-Bart
与传统的经颅直流电刺激(HD-TDC)相比，高清晰度经颅直流电刺激(HD-TDC)提供了更好的针对特定脑区的焦点，以调节神经兴奋性。HD-tdcs与刺激过程中头皮感觉增加有关，可能会使传统的tdcs伪装方法因缺乏失明而无效。在这里，我们报告了一种新方法的验证数据，该方法用于模拟HD-tDCS研究中的假情况。31名参与者在持续的积极刺激和虚假刺激的20分钟内完成了感觉评级。超过一半的参与者报告说在实验期间感受到了刺激。假刺激和主动刺激之间的感觉等级在统计学上没有显著差异。此外，当参与者接受虚假刺激时，他们无法猜出高于机率水平的答案。(C)2015 Elsevier Inc.保留所有权利。
High Definition Transcranial Direct Current Stimulation (HD-tDCS) offers improved focality for targeting specific brain areas to modulate neural excitability, compared to conventional tDCS. HD-tDCS is associated with increased scalp sensation during stimulation, potentially rendering conventional tDCS sham methods ineffective due to lack of blinding. Here we report validation data on a novel method for modeling the sham condition in HD-tDCS studies. Thirty-one participants completed sensation ratings during 20 min of continuous active versus sham stimulation. Over half of the participants reported feeling the stimulation for the duration of the experiment. There were no statistically significant differences in sensation ratings between sham and active stimulation. Further, participants were unable to guess above chance level when they received sham stimulation. (C) 2015 Elsevier Inc. All rights reserved.