First-trimester prediction of preterm birth using ADAM12, PAPP-A, uterine artery Doppler, and maternal characteristics
First-trimester prediction of preterm birth using ADAM12, PAPP-A, uterine artery Doppler, and maternal characteristics
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DOI：
10.1002/pd.3949
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发表时间：
2012-10-01
影响因子：
3
通讯作者：
Odibo, Anthony O.
中科院分区：
文献类型：
--
作者：
Goetzinger, Katherine R.;Cahill, Alison G.;Odibo, Anthony O.
目的探讨妊娠早期血浆去整合素和金属蛋白酶12(ADAM12)、妊娠相关血浆蛋白A(PAPP-A)、子宫动脉多普勒和母体特征在预测早产(PTB)中的作用。方法这是一项前瞻性队列研究，研究对象为妊娠早期进行非整倍体筛查的患者。用免疫法测定孕妇血清ADAM12和PAPP-A水平，计算平均子宫动脉多普勒搏动指数。主要结果是肺结核。
Objective The objective of this study was to estimate the efficiency of first-trimester a disintegrin and metalloprotease 12 (ADAM12), pregnancy-associated plasma protein A (PAPP-A), uterine artery Doppler, and maternal characteristics in the prediction of preterm birth (PTB). Methods This was a prospective cohort study of patients presenting for first-trimester aneuploidy screening. Maternal serum ADAM12 and PAPP-A levels were measured by immunoassay, and mean uterine artery Doppler pulsatility indices were calculated. The primary outcome was PTB