Redefining type 2 diabetes: 'diabesity' or 'obesity dependent diabetes mellitus'?
Redefining type 2 diabetes: 'diabesity' or 'obesity dependent diabetes mellitus'?
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DOI：
10.1046/j.1467-789x.2000.00013.x
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发表时间：
2000-10-01
期刊：
影响因子：
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通讯作者：
Finer, N
中科院分区：
文献类型：
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作者：
Astrup, A;Finer, N
2型糖尿病被糖尿病医生认为是一种复杂的异质性疾病，病因学知之甚少，除了当暴露于典型的西方生活方式时，有一种强烈的遗传倾向变得明显。我们的临床目标正由控制疾病转向预防疾病，我们是否需要等待更多的病因学和病理生理学研究，然后才制定预防策略？不，病理生理学可能知之甚少，但现在有确凿的证据表明2型糖尿病是一种肥胖疾病。新的对照临床试验表明，只要减轻5%的体重就足以防止大多数糖耐量受损的肥胖受试者发展为2型糖尿病。由于2型糖尿病是肥胖依赖性的，肥胖是2型糖尿病的主要病因，我们建议采用“糖尿病肥胖”一词。
Type 2 diabetes is considered by diabetes physicians as a complex and heterogeneous disease with a poorly understood aetiology, apart from the fact that there is a strong genetic propensity that becomes overt when exposed to a typical Western lifestyle. Our clinical targets are now moving from controlling the disease to preventing it. Do we need to await more research on the aetiology and pathophysiology before establishing a preventive strategy? No, the pathophysiology may be poorly understood, but there is now solid evidence that type 2 diabetes is a disease of fatness. New, controlled, clinical trials show that as little as 5% weight loss is sufficient to prevent most obese subjects with impaired glucose tolerance developing type 2 diabetes. Since type 2 diabetes is obesity dependent, and obesity is the main aetiogical cause of type 2 diabetes, we propose the term 'diabesity' should be adopted.