Risk Evaluation of Endocrine-Disrupting Chemicals: Effects of Developmental Exposure to Low Doses of Bisphenol A on Behavior and Physiology in Mice (Mus musculus).
Risk Evaluation of Endocrine-Disrupting Chemicals: Effects of Developmental Exposure to Low Doses of Bisphenol A on Behavior and Physiology in Mice (Mus musculus).
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DOI：
10.1177/1559325815610760
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发表时间：
2015-10
期刊：
影响因子：
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通讯作者：
Vom Saal FS
中科院分区：
文献类型：
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作者：
Gioiosa L;Palanza P;Parmigiani S;Vom Saal FS
我们在这里回顾我们的研究早期暴露于低剂量的雌激素内分泌干扰化学双酚A（BPA）的行为和代谢的CD-1小鼠。从妊娠第11天（GD）至分娩（产前暴露），小鼠在子宫内暴露于10 µg/kg体重/天BPA或无BPA（对照组），或从出生至出生后第7天（出生后暴露）通过母乳暴露于BPA。双酚A暴露导致性二态行为的长期破坏。出生前和出生后暴露于BPA的女性表现出与对照男性相似的焦虑和行为特征。我们还评估了在产前暴露的成年雄性后代中的代谢效应，这些后代的母体（GD 9至18）喂食BPA，剂量范围为5至50 000 µg/kg/d。在BPA剂量低于未观察到不良作用水平（5000 µg/kg/d）时，雄性动物的许多代谢指标（从食物摄入量到葡萄糖调节）出现了与年龄相关的显著变化。与之前的研究结果一致，低剂量但不高剂量的BPA对许多结果产生了显著影响。这些发现进一步证明了发育期暴露于低剂量的内分泌干扰物BPA可能对人类健康造成的潜在风险，胎儿和婴儿非常脆弱。
We review here our studies on early exposure to low doses of the estrogenic endocrine-disrupting chemical bisphenol A (BPA) on behavior and metabolism in CD-1 mice. Mice were exposed in utero from gestation day (GD) 11 to delivery (prenatal exposure) or via maternal milk from birth to postnatal day 7 (postnatal exposure) to 10 µg/kg body weight/d of BPA or no BPA (controls). Bisphenol A exposure resulted in long-term disruption of sexually dimorphic behaviors. Females exposed to BPA pre- and postnatally showed increased anxiety and behavioral profiles similar to control males. We also evaluated metabolic effects in prenatally exposed adult male offspring of dams fed (from GD 9 to 18) with BPA at doses ranging from 5 to 50 000 µg/kg/d. The males showed an age-related significant change in a number of metabolic indexes ranging from food intake to glucose regulation at BPA doses below the no observed adverse effect level (5000 µg/kg/d). Consistent with prior findings, low but not high BPA doses produced significant effects for many outcomes. These findings provide further evidence of the potential risks that developmental exposure to low doses of the endocrine disrupter BPA may pose to human health, with fetuses and infants being highly vulnerable.