ADENOSINE MODULATION OF AMYGDALA KINDLING
ADENOSINE MODULATION OF AMYGDALA KINDLING
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DOI：
10.1016/0014-4886(84)90212-7
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发表时间：
1984-01-01
影响因子：
5.3
通讯作者：
GODDARD, GV
中科院分区：
文献类型：
--
作者：
DRAGUNOW, M;GODDARD, GV
为了验证抑制性神经调节剂腺苷抑制点燃的假说，在每天电刺激杏仁核前20分钟向大鼠全身注射腺苷摄取阻断剂罂粟碱或腺苷拮抗剂氨茶碱。在发作阈值下，研究了罂粟碱、腺苷、2-氯腺苷以及腺苷拮抗剂异丁基甲基黄嘌呤和咖啡因对杏仁核诱发癫痫发作的影响。罂粟碱抑制点燃，而氨茶碱促进点燃。腺苷激动剂有抗惊厥作用，拮抗剂有促惊厥作用，主要是延长后放电时程。反复注射氨茶碱，在没有电刺激的情况下，诱发癫痫发作。显然，腺苷可以调节点燃并影响癫痫发作过程。
To test the hypothesis that kindling is restrained by the inhibitory neuromodulator adenosine, the adenosine uptake blocker papaverine, or the adenosine antagonist aminophylline were injected systemically into rats 20 min before each daily electrical stimulation of the amygdala. The effects on amygdala-triggered seizures of papaverine, adenosine, 2-chloroadenosine, and the adenosine antagonists isobutylmethylxanthine and caffeine were also investigated at seizure threshold. Papaverine inhibited kindling, whereas aminophylline accelerated kindling. The adenosine agonists had anticonvulsant effects on seizures, and the antagonists had proconvulsant effects which involved, primarily, the lengthening of afterdischarge duration. Aminophylline injected repeatedly, in the absence of electrical stimulation, induced seizures. Apparently, adenosine can modulate kindling and affect the seizure process.