Social regulation of leukocyte homeostasis: The role of glucocorticoid sensitivity
Social regulation of leukocyte homeostasis: The role of glucocorticoid sensitivity
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DOI：
10.1016/j.bbi.2008.02.006
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发表时间：
2008-10-01
影响因子：
15.1
通讯作者：
Cole, Steve W.
中科院分区：
文献类型：
--
作者：
Cole, Steve W.
最近的小规模基因组分析表明，在经历慢性社会隔离的个体中，内源性糖皮质激素对促炎基因表达的生理调节可能受到损害。本研究评估了大量老年人样本中白细胞对糖皮质激素调节的敏感性和主观社会隔离之间的关系。初步分析证实，循环中性粒细胞百分比升高，循环淋巴细胞和单核细胞百分比受到抑制，与循环皮质醇水平成正比。然而，在报告偶尔或频繁经历主观社交孤立的个体中，白细胞对内源性糖皮质激素的敏感性被取消。这一发现在非参数单变量分析和控制各种生物、社会、行为和心理混杂因素的多变量线性模型中都成立。目前的结果表明，社会因素可能改变免疫细胞对下丘脑-垂体-肾上腺轴生理调节的敏感性，最终可能导致与社会隔离相关的身体健康风险增加。(C)2008 Elsevier Inc.保留所有权利。
Recent small-scale genomics analyses suggest that physiologic regulation of pro-inflammatory gene expression by endogenous glucocorticoids may be compromised in individuals who experience chronic social isolation. The present study assessed the relationship between leukocyte distributional sensitivity to glucocorticoid regulation and subjective social isolation in a large population-based sample of older adults. Initial analyses confirmed that circulating neutrophil percentages were elevated, and circulating lymphocyte and monocyte percentages were suppressed, in direct proportion to circulating cortisol levels. However, leukocyte distributional sensitivity to endogenous glucocorticoids was abrogated in individuals reporting either occasional or frequent experiences of subjective social isolation. This finding held in both non-parametric univariate analyses and in multivariate linear models controlling for a variety of biological, social, behavioral, and psychological confounders. The present results suggest that social factors may alter immune cell sensitivity to physiologic regulation by the hypothalamic-pituitary-adrenal axis in ways that could ultimately contribute to the increased physical health risks associated with social isolation. (C) 2008 Elsevier Inc. All rights reserved.