Typical 2-Cys peroxiredoxins--structures, mechanisms and functions.
Typical 2-Cys peroxiredoxins--structures, mechanisms and functions.
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DOI:
10.1111/j.1742-4658.2009.06985.x
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发表时间:
2009-05
期刊:
影响因子:
--
通讯作者:
Poole LB
中科院分区:
文献类型:
--
作者:
Hall A;Karplus PA;Poole LB
Peroxiredoxins (Prxs) are abundant cellular antioxidant proteins which help control intracellular peroxide levels. These proteins may also function, in part through an evolved sensitivity of some Prxs toward peroxide-mediated inactivation, in hydrogen peroxide signaling in eukaryotes. This review summarizes recent progress in our understanding of the catalytic and regulatory mechanisms of “typical 2-Cys” Prxs and of the biological roles that these important enzymes play in oxidative stress and non-stress related cellular signaling.
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