Typical 2-Cys peroxiredoxins--structures, mechanisms and functions.

Typical 2-Cys peroxiredoxins--structures, mechanisms and functions.
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DOI:
10.1111/j.1742-4658.2009.06985.x
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发表时间:
2009-05
期刊:
The FEBS journal
影响因子:
--
通讯作者:
Poole LB
Poole LB
中科院分区:
其他
文献类型:
--
作者:
Hall A;Karplus PA;Poole LB

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过氧化物还原酶(Peroxiredoxins,Prxs)是一种丰富的细胞抗氧化蛋白,可帮助控制细胞内过氧化物水平。这些蛋白质也可能在真核生物中的过氧化氢信号传导中起作用,部分是通过一些Prxs对过氧化物介导的失活的进化敏感性。本文综述了“典型2-Cys”Prxs的催化和调节机制以及这些重要酶在氧化应激和非应激相关细胞信号传导中的生物学作用的最新进展。
Peroxiredoxins (Prxs) are abundant cellular antioxidant proteins which help control intracellular peroxide levels. These proteins may also function, in part through an evolved sensitivity of some Prxs toward peroxide-mediated inactivation, in hydrogen peroxide signaling in eukaryotes. This review summarizes recent progress in our understanding of the catalytic and regulatory mechanisms of “typical 2-Cys” Prxs and of the biological roles that these important enzymes play in oxidative stress and non-stress related cellular signaling.
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