Primary localized cutaneous amyloidosis: a sign of immune dysregulation?
Primary localized cutaneous amyloidosis: a sign of immune dysregulation?
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DOI：
10.1111/j.1365-4632.2009.03799.x
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发表时间：
2009-04-01
影响因子：
3.6
通讯作者：
Ghosn, Samer
中科院分区：
文献类型：
--
作者：
Dahdah, Maurice J.;Kurban, Mazen;Ghosn, Samer
原发性局限性皮肤淀粉样变性（PLCA）的临床表现通常局限于皮肤。其确切的发病机制尚未完全阐明。越来越多的文献报道将PLCA与各种自身免疫性/免疫性疾病联系起来，提示潜在的免疫介导因素可能与之有关。我们报告了一例结节病和一例伊加肾病与广泛性黄斑淀粉样变性相关，将这两种情况添加到与PLCA相关的其他自身免疫性/免疫性疾病的列表中。特别是那些广泛受累的患者，可能患有相关的自身免疫/免疫疾病，这增加了共同的潜在免疫介导机制的可能性。
The manifestations of primary localized cutaneous amyloidosis (PLCA) are usually limited to the skin. The exact etiopathogenesis of PLCA has not been clearly elucidated yet. An increasing number of reports in the literature that associate PLCA with various autoimmune/immune disorders suggest that underlying immune-mediated factors may be implicated.We report a case of sarcoidosis and a case of IgA nephropathy in association with extensive macular amyloidosis, adding these two conditions to the list of other autoimmune/immune disorders associated with PLCA.At least a subset of PLCA patients, especially those with extensive involvement, may have associated autoimmune/immune disorders raising the possibility of a common underlying immune-mediated mechanism.