Cannabinoid Oil Vaping-Associated Lung Injury and its Radiographic Appearance
Cannabinoid Oil Vaping-Associated Lung Injury and its Radiographic Appearance
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DOI：
10.1016/j.amjmed.2019.10.032
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发表时间：
2020-07-01
影响因子：
5.9
通讯作者：
Judson, Marc A.
中科院分区：
文献类型：
--
作者：
Conuel, Edward J.;Chieng, Hau C.;Judson, Marc A.
背景：与大麻素油雾化相关的肺损伤正迅速成为一个严重的公共卫生问题。我们描述了5例患者的临床和影像学表现与雾化大麻素油相关的肺损伤在单一机构看到。结果：本院收治的5例疑似电子烟相关肺损伤患者中，4例需要补氧，4例均住院。三名病人需要住进重症监护室。没有患者需要机械通气。所有患者均表现出一致的影像学表现：弥漫性双侧磨玻璃肺混浊，而外围区除外。3例患者行支气管肺泡灌洗，其中2例发现含脂巨噬细胞。所有病人都顺利出院。其中4例只接受支持性治疗，而第5例需要静脉注射后再口服皮质类固醇。结论：我们报告了本院5例大麻素油雾化相关肺损伤患者的临床和影像学表现。所有患者均表现出一致的胸片损伤模式。大多数患者对支持性治疗有反应，尽管其中一人需要添加皮质类固醇。支气管肺泡灌洗结果提示这种损伤可能与中毒性的类脂性肺炎有关。(C) 2019 Elsevier Inc.版权所有。
BACKGROUND: Lung injury associated with cannabinoid oil vaping is rapidly becoming a serious public health concern. We describe the clinical and radiographic presentations of 5 patients with lung injury associated with vaping cannabinoid oils seen at a single institution.RESULTS: Of the 5 patients with suspected vaping-associated lung injury seen at our institution, 4 required supplemental oxygen, and all these 4 were admitted to the hospital. Three patients required admission to the intensive care unit. None of the patients required mechanical ventilation. All patients demonstrated a consistent radiologic appearance of diffuse bilateral ground-glass lung opacities that spared the extreme periphery. Three patients underwent bronchoalveolar lavage, which revealed lipid-laden macrophages in 2 of them. All patients were successfully discharged from the hospital. Four received only supportive care, while the fifth required intravenous followed by oral corticosteroids.CONCLUSIONS: We report the clinical and radiographic presentation of 5 patients at our institution with cannabinoid oil vaping-associated lung injury. All patients displayed a consistent chest radiographic pattern of injury. Most responded to supportive care, although one required the addition of corticosteroids. Bronchoalveolar lavage results suggest that this injury may related to a toxic form of lipoid pneumonia. (C) 2019 Elsevier Inc. All rights reserved.