Platelet-rich plasma versus platelet-poor plasma in the management of chronic diabetic foot ulcers: a comparative study
Platelet-rich plasma versus platelet-poor plasma in the management of chronic diabetic foot ulcers: a comparative study
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DOI：
10.1111/j.1742-481x.2011.00797.x
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发表时间：
2011-06-01
影响因子：
3.1
通讯作者：
Safe, Ikram
中科院分区：
文献类型：
--
作者：
Setta, Hany Saad;Elshahat, Ahmed;Safe, Ikram
不愈合的糖尿病足溃疡和由此产生的潜在截肢给医疗保健系统带来了巨大的成本，并降低了患者的生活质量。糖尿病足溃疡治疗的目标是尽快闭合伤口。在过去十年中，使用富血小板血浆（PRP）来促进伤口愈合的情况急剧增加。然而，在文献中存在争议，关于这个程序的额外好处。本研究的目的是研究与贫血小板血浆（PPP）相比，血小板释放对慢性糖尿病溃疡愈合的效率。本研究纳入了24例慢性糖尿病溃疡患者。随机分为PRP组和PPP组，每组12例。结果显示，PRP组愈合速度明显快于对照组（P <0.05）。PRP促进慢性糖尿病足溃疡的愈合。
Non healing diabetic foot ulcers and the resulting potential amputations present significant costs to the health care system and reduce patient quality of life. The goal of diabetic foot ulcer treatment is to obtain wound closure as expeditiously as possible. The use of platelet-rich plasma (PRP) to enhance wound healing has increased dramatically over the last decade. However, controversies exist in the literature regarding the added benefit of this procedure. The aim of this study is to investigate the efficiency of platelet releasate on the healing of chronic diabetic ulcers in comparison with platelet-poor plasma (PPP). This study included 24 patients with chronic diabetic ulcers. They were systematically randomised into two groups: PRP group (n = 12) and PPP group (n = 12). The results showed that healing in PRP group was significantly faster (P < 0 center dot 005). PRP enhances healing of chronic diabetic foot ulcers.