Multi-drug delivery to tumor cells via micellar nanocarriers.
Multi-drug delivery to tumor cells via micellar nanocarriers.
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DOI：
10.1016/j.ijpharm.2011.07.033
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发表时间：
2011-10-31
影响因子：
5.8
通讯作者：
Tan, Chalet
中科院分区：
文献类型：
--
作者：
Katragadda, Usha;Teng, Quincy;Rayaprolu, Bindhu Madhavi;Chandran, Thripthy;Tan, Chalet
本研究的目的是开发用于同时递送紫杉醇和17-烯丙基氨基-17-去甲氧基格尔德霉素（17-AAG）用于癌症治疗的胶束纳米载体。采用溶剂蒸发法将紫杉醇和17-AAG同时负载到聚合物胶束中。评估了两种候选纳米载体构建体--聚乙二醇-聚（D，L-乳酸）（PEG-PLA）胶束和聚乙二醇-二硬脂酰磷脂酰乙醇胺/生育酚聚乙二醇1000（PEG-DSPE/TPGS）混合胶束--负载药物的释放动力学。与PEG-PLA胶束相比，PEG-DSPE/TPGS混合胶束包封紫杉醇和17-AAG后，药物的释放半衰期明显延长。通过1H NMR分析证实紫杉醇和17-AAG同时掺入PEG-DSPE/TPGS混合胶束中。紫杉醇/17-AAG-PEG-DSPE/TPGS混合胶束对人卵巢癌SKOV-3细胞增殖的抑制作用与联合游离药物相当。PEG-DSPE/TPGS混合胶束可能为紫杉醇/17-AAG联合治疗提供一种新的、有利的给药途径。
The aim of this study was to develop micellar nanocarriers for concomitant delivery of paclitaxel and 17-allylamino-17-demethoxygeldanamycin (17-AAG) for cancer therapy. Paclitaxel and 17-AAG were simultaneously loaded into polymeric micelles by a solvent evaporation method. Two candidate nanocarrier constructs, polyethylene glycol-poly(D, L-lactic acid) (PEG-PLA) micelles and PEG-distearoylphosphatidylethanolamine/tocopheryl polyethylene glycol 1000 (PEG-DSPE/TPGS) mixed micelles, were assessed for the release kinetics of the loaded drugs. Compared to PEG-PLA micelles, entrapment of paclitaxel and 17-AAG into PEG-DSPE/TPGS mixed micelles resulted in significantly prolonged release half-lives. The simultaneous incorporation of paclitaxel and 17-AAG into PEG-DSPE/TPGS mixed micelles was confirmed by 1H NMR analysis. Paclitaxel/17-AAG-loaded PEG-DSPE/TPGS mixed micelles were as effective in blocking the proliferation of human ovarian cancer SKOV-3 cells as the combined free drugs. PEG-DSPE/TPGS mixed micelles may provide a novel and advantageous delivery approach for paclitaxel/17-AAG combination therapy.
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影响因子：
50.5
作者：
Kim, D. -W.;Kim, S. -Y.;Heo, D. S.
通讯作者：
Heo, D. S.
影响因子：
11.2
作者：
Sawai, Ayana;Chandarlapaty, Sarat;Solit, David B.
通讯作者：
Solit, David B.
影响因子：
11.5
作者：
Kim, TY;Kim, DW;Bang, YJ
通讯作者：
Bang, YJ
影响因子：
5.7
作者：
Sain, Nivedita;Krishnan, Bhavani;Jackman, Ann L.
通讯作者：
Jackman, Ann L.
DOI：
10.1158/1078-0432.ccr-08-1006
发表时间：
2008-10-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Tse AN;Klimstra DS;Gonen M;Shah M;Sheikh T;Sikorski R;Carvajal R;Mui J;Tipian C;O'Reilly E;Chung K;Maki R;Lefkowitz R;Brown K;Manova-Todorova K;Wu N;Egorin MJ;Kelsen D;Schwartz GK
通讯作者：
Schwartz GK