Brain correlates of recognition of communicative interactions from biological motion in schizophrenia
Brain correlates of recognition of communicative interactions from biological motion in schizophrenia
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DOI：
10.1017/s0033291717003385
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发表时间：
2017-11
影响因子：
6.9
通讯作者：
Ł. Okruszek;M. Wordecha;M. Jarkiewicz;B. Kossowski;J. Lee;A. Marchewka
中科院分区：
文献类型：
--
作者：
Ł. Okruszek;M. Wordecha;M. Jarkiewicz;B. Kossowski;J. Lee;A. Marchewka
研究背景对交际互动的识别是一种复杂的社会认知能力，它与健康个体的特定神经活动有关。然而，在精神分裂症（SCZ）患者中，全身运动的交流互动处理的神经相关性尚不清楚。因此，本研究的目的是检查相关的神经活动与识别的沟通互动SCZ使用显示器的二元互动降级到极简主义的点光演示。方法26名健康对照者和25名SCZ被试被要求判断两个仅由点光源显示的智能体是在交流还是独立行动。分别用一般线性模型和广义心理生理相互作用方法研究任务相关活动和脑结构的功能连接。结果HC对每种动作类型的识别效率均显著高于SCZ。在神经水平上，右后上级颞沟（pSTS）的活动被观察到更高的交流与个人行动处理相比，在HC与SCZ。重要的是，增加连接的右pSTS与结构相关的心智化（左pSTS）和镜像网络（左额区）观察HC，但不是在SCZ，在介绍社会交往。结论：右pSTS的招募不足，一个已知在社会加工中起关键作用的结构，也可能是SCZ高阶社会认知缺陷的重要原因。此外，右pSTS的任务相关连接性降低可能导致精神分裂症患者在社会认知过程中减少使用额外的信息来源（例如运动共振信号）。
Background Recognition of communicative interactions is a complex social cognitive ability which is associated with a specific neural activity in healthy individuals. However, neural correlates of communicative interaction processing from whole-body motion have not been known in patients with schizophrenia (SCZ). Therefore, the current study aims to examine the neural activity associated with recognition of communicative interactions in SCZ by using displays of the dyadic interactions downgraded to minimalistic point-light presentations. Methods Twenty-six healthy controls (HC) and 25 SCZ were asked to judge whether two agents presented only by point-light displays were communicating or acting independently. Task-related activity and functional connectivity of brain structures were examined with General Linear Model and Generalized Psychophysiological Interaction approach, respectively. Results HC were significantly more efficient in recognizing each type of action than SCZ. At the neural level, the activity of the right posterior superior temporal sulcus (pSTS) was observed to be higher in HC compared with SCZ for communicative v. individual action processing. Importantly, increased connectivity of the right pSTS with structures associated with mentalizing (left pSTS) and mirroring networks (left frontal areas) was observed in HC, but not in SCZ, during the presentation of social interactions. Conclusion Under-recruitment of the right pSTS, a structure known to have a pivotal role in social processing, may also be of importance for higher-order social cognitive deficits in SCZ. Furthermore, decreased task-related connectivity of the right pSTS may result in reduced use of additional sources of information (for instance motor resonance signals) during social cognitive processing in schizophrenia.