Induction and repair of cyclobuta-dithymidine photoproducts in hamster skin by solar-simulated UV radiation.
Induction and repair of cyclobuta-dithymidine photoproducts in hamster skin by solar-simulated UV radiation.
复制标题
通过模拟太阳紫外线辐射诱导和修复仓鼠皮肤中的环丁二胸苷光产物。
DOI：
10.1016/1011-1344(89)80017-x
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Creasey,JS
中科院分区：
文献类型：
--
作者：
Strickland,PT;Creasey,JS
The induction and repair of cyclobuta-dithymidine (T<⪢T) photoproducts in hamster skin was measured following exposure to artificial solar radiation. DNA extracted from irradiated hamster epidermis was analyzed by enzyme-linked immunosorbent assay (ELISA) using a monoclonal antibody specific for T<⪢T photoproducts. Between 49% and 58% of T<⪢T antibody binding sites were eliminated from DNA by 24 h after radiation exposures comparable with approximately 60 – 120 min of midday sunlight, whereas all detectable T<⪢T binding sites were eliminated by 24 h after a radiation exposure comparable with 30 min of sunlight.
