Regulation of gene transcription by Polycomb proteins.
Regulation of gene transcription by Polycomb proteins.
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DOI：
10.1126/sciadv.1500737
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发表时间：
2015-12
期刊：
影响因子：
13.6
通讯作者：
Di Croce L
中科院分区：
文献类型：
--
作者：
Aranda S;Mas G;Di Croce L
新的发现扩展了哺乳动物Polycomb蛋白复合物在基因调控和3D染色质构象上的功能。蛋白质的Polycomb组（PcG）定义了一组因子，这些因子在物理上关联并起作用以维持从胚胎到成体阶段的细胞的位置身份。PcG一直被认为是基因转录程序表观遗传维持的典范模型。尽管密集的研究努力揭示PcG蛋白的分子作用机制，几个基本的问题仍然没有解决：有多少不同的PcG复合物存在于哺乳动物细胞？PcG复合物如何靶向特定位点？PcG如何调节转录？在这篇综述中，我们讨论了哺乳动物细胞中的PcG复合物的多样性，检查新发现的模式的招聘染色质，并强调了最新的见解PcG的转录调控和三维染色质构象的功能的分子机制。
New findings extend the functionality of mammalian Polycomb protein complexes on gene regulation and 3D chromatin conformation. The Polycomb group (PcG) of proteins defines a subset of factors that physically associate and function to maintain the positional identity of cells from the embryo to adult stages. PcG has long been considered a paradigmatic model for epigenetic maintenance of gene transcription programs. Despite intensive research efforts to unveil the molecular mechanisms of action of PcG proteins, several fundamental questions remain unresolved: How many different PcG complexes exist in mammalian cells? How are PcG complexes targeted to specific loci? How does PcG regulate transcription? In this review, we discuss the diversity of PcG complexes in mammalian cells, examine newly identified modes of recruitment to chromatin, and highlight the latest insights into the molecular mechanisms underlying the function of PcGs in transcription regulation and three-dimensional chromatin conformation.