SUNDOWNING AND RATE OF DECLINE IN MENTAL FUNCTION IN ALZHEIMERS-DISEASE
SUNDOWNING AND RATE OF DECLINE IN MENTAL FUNCTION IN ALZHEIMERS-DISEASE
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DOI：
10.1159/000107035
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发表时间：
1992-09-01
期刊：
影响因子：
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通讯作者：
TINKLENBERG, JR
中科院分区：
文献类型：
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作者：
BLIWISE, DL;YESAVAGE, JA;TINKLENBERG, JR
长期以来，破坏性行为的夜间加剧一直被认为是阿尔茨海默病（AD）的常见现象，然而，这种睡眠中断的基础尚不清楚。在这项研究中，60名可能患有AD的患者的护理人员被要求在24小时内指出7种破坏性行为中任何一种发生的典型时间模式。破坏性行为的模式被定义为日落（下午，晚上或夜间恶化），早晨恶化，以及作为一种非暂时性的特定行为破坏模式。约28%的患者有日落症状，而20%的患者有晨间加重症状。日落与迷你精神状态考试（MMSE）的总分无关，然而，日落与MMSE上选定的心理功能随着时间的推移下降的速度更快有关。具体来说，意念动力练习能力的下降与日落有关。
Nocturnal exacerbation of disruptive behaviors has long been recognized as a common occurrence in Alzheimer's disease (AD), however the basis for such sleep disruption is poorly understood. In this study, caregivers of 60 patients with probable/possible AD were asked to indicate the typical temporal pattern of occurrence of any of seven disruptive behaviors over the 24-hour day. Patterns of disruptive behavior were defined as sundowning (afternoon, evening, or nocturnal exacerbation), morning exacerbation, and as a nontemporally specific pattern of behavioral disruption. About 28% of the patients were reported to sundown whereas 20% showed a pattern of morning exacerbation. Sundowning was unrelated to total score on the Mini-Mental State Exam (MMSE), however, sundowning was related to a faster rate of decline over time in selected mental functions on the MMSE. Specifically, declines in ideokinetic praxis abilities were related to sundowning.