Metabolism of arylhydrazines by cytochrome P-450 mixed function oxidases and prostaglandin(H)synthase from mouse lungs.
Metabolism of arylhydrazines by cytochrome P-450 mixed function oxidases and prostaglandin(H)synthase from mouse lungs.
复制标题
小鼠肺部细胞色素 P-450 混合功能氧化酶和前列腺素 (H) 合酶对芳基肼的代谢。
DOI：
10.1016/0304-3835(87)90010-3
复制
发表时间：
1987
期刊：
影响因子：
9.7
通讯作者：
Lawson,T
中科院分区：
文献类型：
--
作者：
Lawson,T
The arylhydrazines 4-methylphenylhydrazine hydrochloride,N′-acetyl-4-methylphenylhydrazine andN′-acetyl-4-hydroxymethylphenylhydrazine (HMPH) were metabolized by ram seminal vesicle prostaglandin(H)synthase (P(H)S) and by cytochromeP-450- and P(H)S-dependent enzymes from mouse lung. Based on theKm-values, the cytochromeP-450 enzymes were the most efficient, suggesting that they would be responsible for the metabolic activation of these compounds in vivo. CytochromeP-450-dependent metabolism was inhibited by metyrapone and SKF-525A, ruling out the involvement of flavin mono-oxygenase. Agaritine, an arylhydrazide, was poorly metabolized by both systems.
