Nasal administration of albuterol: an alternative route of delivery
Nasal administration of albuterol: an alternative route of delivery
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DOI：
10.1211/0022357044283
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发表时间：
2004-10-01
影响因子：
3.3
通讯作者：
Hussain, MA
中科院分区：
文献类型：
--
作者：
Hussain, AA;Dakkuri, A;Hussain, MA
使用定量吸入器输送沙丁胺醇（一种β(2)-选择性肾上腺素能激动剂）存在一些缺点，特别是对于儿童和老年人。本研究旨在评估鼻内递送沙丁胺醇的有效性，并将该递送途径与气管内和静脉内递送进行比较。使用麻醉、人工通气豚鼠的肺功能的三个参数（最大呼气流量峰值、50%肺活量时的最大呼气流量和肺总容量）来确定沙丁胺醇对乙酰胆碱引起的支气管收缩反应的保护程度。还测量了心率。尽管鼻内沙丁胺醇在吸收的最初阶段引起较慢的保护作用，但该药物在鼻内或气管内给药时显示出同样有效。相比之下，尽管静脉注射沙丁胺醇最初效果显着，但其影响肺功能的能力却迅速减弱。不同治疗组之间未检测到心率有统计学上的显着差异。总之，鼻内沙丁胺醇可以作为定量吸入器的替代品，用于治疗急性支气管痉挛和预防运动诱发的哮喘，特别是对于儿童和老年人。
The use of metered-dose inhalers for the delivery of albuterol, a beta(2)-selective adrenergic agonist, is associated with drawbacks, especially in children and the elderly. This investigation was designed to assess the effectiveness of albuterol delivered intranasally and to compare this delivery route with intratracheal and intravenous delivery. Three parameters of pulmonary function (peak maximal expiratory flow, maximal expiratory flow at 50% vital capacity, and total lung capacity) in anaesthetized, artificially ventilated guinea pigs were used to determine the degree of protection produced by albuterol against bronchoconstrictor responses provoked by acetylcholine. The heart rate was also measured. Although intranasal albuterol induced a slower protective action during the very initial phase of absorption, the drug was shown to be equally effective when administered either intranasally or intratracheally. in contrast, despite a significant effect initially in the case of intravenous albuterol, its ability to influence pulmonary function faded rather rapidly. No statistically significant differences in heart rate could be detected among the different treatment groups. In conclusion, intranasal albuterol may offer an alternative to metered-dose inhalers for the treatment of acute bronchospasm and for prevention of exercise-induced asthma, especially for children and the elderly.