Cancer risk among patients with type 2 diabetes: A real-world study in Shanghai, China2?????????????:????????????
Cancer risk among patients with type 2 diabetes: A real-world study in Shanghai, China2?????????????:????????????
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2 型糖尿病患者的癌症风险：中国上海的一项真实世界研究
DOI：
10.1111/1753-0407.12926
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发表时间：
2019-11-01
影响因子：
4.5
通讯作者：
Ning, Guang
中科院分区：
文献类型：
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作者：
Qi, Jiying;He, Ping;Ning, Guang
背景本研究的目的是调查2型糖尿病（T2 D）患者与中国普通人群相比23种常见癌症的风险。2013年7月至2016年12月，对20- 99岁的患者进行了癌症发病率随访，直至2017年12月。8485例新诊断的癌症被确定。总癌症的标化发病比（SIR）男性和女性分别为1.34和1.62。在男性T2 D患者中，前列腺癌（SIR最高为1.86）、血液（白血病、淋巴瘤）、皮肤癌、甲状腺癌、肾癌、肝癌、胰腺癌、肺癌、结直肠癌和胃癌的风险显著增加。患食道癌的风险显著降低。在患有T2 D的女性中，鼻咽癌（最高SIR为2.33）、肝癌、食道癌、甲状腺癌、肺癌、胰腺癌、血癌（淋巴瘤、白血病）、子宫癌、结直肠癌、乳腺癌、宫颈癌和胃癌的风险显著更高。与此相反，女性T2 D患者胆囊癌的风险显著降低。结论本研究显示T2 D患者总体和某些部位特异性癌症的风险显著增加。我们建议在T2 D患者中建立定期癌症特异性筛查和预防护理的策略是必要的。两个？23岁？2013年？七？？2016年？12年？410 191？两个？(?? 20-99？），？2017年？12岁？8485？2？（标准化发病率比，SIRs）？一点三四？1.62磅，(SIR??: 1.86）？(???????)?????????????????????????????????????,???????????????????,??? (SIR??: 2.33）？？(???????)?????????????????????????????????,????????????????????????, 2？2？？？？？？？？？？？？？？？
BackgroundThe aim of this study was to investigate the risk of 23 common types of cancer among patients with type 2 diabetes (T2D) compared with the general Chinese population.MethodsBased on the Shanghai Hospital Link database, 410191 patients with T2D (age 20-99years) were identified from July 2013 to December 2016, and were followed-up for cancer incidence until December 2017.ResultsIn all, 8485 cases of newly diagnosed cancer were identified. The standardized incidence ratios (SIRs) of total cancer were 1.34 and 1.62 among males and females, respectively. Among males with T2D, the risk of cancer of the prostate (highest SIR of 1.86), blood (leukemia, lymphoma), skin, thyroid, kidney, liver, pancreas, lung, colorectum, and stomach was increased significantly. There was a significant decrease in the risk of esophageal cancer. In females with T2D, there were significantly greater risks of cancer of the nasopharynx (highest SIR of 2.33), liver, esophagus, thyroid, lung, pancreas, blood (lymphoma, leukemia), uterus, colorectum, breast, cervix, and stomach. In contrast, there was significantly decrease risk of gallbladder cancer in females with T2D.ConclusionsThis study shows significantly increased risks of overall and some site-specific cancers among patients with T2D. We suggest that establishing strategies for regular cancer-specific screening and prevention care among patients with T2D are necessary.?????????????????,2????????23????????????????????????,?2013?7??2016?12????410 191?2??????(??20-99?),????2017?12??????????????????8485???????????2?????????????????(standardized incidence ratios,SIRs)???1.34?1.62?????????,????(SIR??:1.86)???(???????)?????????????????????????????????????,???????????????????,???(SIR??:2.33)??????????????????????(???????)?????????????????????????????????,????????????????????????,2???????????????????????????????????????2???????????????????????