The Role of miR-150 in Stress-Induced Anxiety-Like Behavior in Mice
The Role of miR-150 in Stress-Induced Anxiety-Like Behavior in Mice
复制标题
miR-150 在小鼠应激诱发的焦虑样行为中的作用
DOI：
10.1007/s12640-018-9943-x
复制
发表时间：
2018-08
影响因子：
3.7
通讯作者：
Fang Li
中科院分区：
文献类型：
--
作者：
Wen-Juan Zhang;Wen-Yu Cao;Yan-Qing Huang;Yan-Hui Cui;Bo-Xuan Tu;Lai-Fa Wang;Guang-Jing Zou;Yu Liu;Zhao-Lan Hu;Rong Hu;Chang-Qi Li;Xiao-Wei Xing;Fang Li
Stress plays a crucial role in several psychiatric disorders, including anxiety. However, the underlying mechanisms remain poorly understood. Here, we used acute stress (AS) and chronic restraint stress (CRS) models to develop anxiety-like behavior and investigate the role of miR-150 in the hippocampi of mice. Corticosterone levels as well as glutamate receptors in the hippocampus were evaluated. We found that anxiety-like behavior was induced after either AS or CRS, as determined by the open-field test (OFT) and elevated plus-maze test (EPM). Increased corticosterone levels were observed in the blood of AS and CRS groups, while the expression of miR-150 mRNA in the hippocampus was significantly decreased. The expressions of GluN2A, GluR1, GluR2, and V-Glut2 in the hippocampus were decreased after either AS or CRS. Hippocampal GAD67 expression was increased by AS but not CRS, and GluN2B expression was decreased by CRS but not AS. Adult miR-150 knockout mice showed anxiety-like behavior, as assessed by the OFT and EPM. The expressions of GluN2A, GluN2B, GluR1, and GluR2 were also downregulated, but the expression of V-Glut2 was upregulated in the hippocampi of miR-150 knockout mice compared with wild-type mice. Interestingly, we found that the miR-150 knockout mice showed decreased dendrite lengths, dendrite branchings, and numbers of dendrite spines in the hippocampus compared with wild-type mice. These results suggest that miR-150 may influence the synaptic plasticity of the hippocampus and play a significant role in stress-induced anxiety-like behavior in adult mice.
登录
查看更多内容
铅暴露通过改变青少年时期的突触可塑性和形态来损害海马相关的学习和记忆
影响因子：
5.1
作者：
Wang Tao;Guan Rui-Li;Liu Ming-Chao;Shen Xue-Feng;Chen Jing Yuan;Zhao Ming-Gao;Luo Wen-Jing
通讯作者：
Luo Wen-Jing
影响因子：
8.2
作者：
Simons, Laura E.;Elman, Igor;Borsook, David
通讯作者：
Borsook, David
影响因子：
2.4
作者：
Wang XQ;Zhong XL;Li ZB;Wang HT;Zhang J;Li F;Zhang JY;Dai RP;Xin-Fu Z;Li CQ;Li ZY;Bi FF
通讯作者：
Bi FF
影响因子：
2.7
作者：
Zamzow, Daniel R.;Elias, Valerie;Legette, LeeCole L.;Choi, Jaewoo;Stevens, J. Fred;Magnusson, Kathy R.
通讯作者：
Magnusson, Kathy R.
影响因子：
4.2
作者：
S. Tsang;H. Vinters;J. Cummings;P. Wong;Christopher P. Chen;M. Lai
通讯作者：
S. Tsang;H. Vinters;J. Cummings;P. Wong;Christopher P. Chen;M. Lai