Pleiotropic effects on mandibular morphology I. Developmental morphological integration and differential dominance
Pleiotropic effects on mandibular morphology I. Developmental morphological integration and differential dominance
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DOI：
10.1002/jez.b.00009
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发表时间：
2003-04-15
影响因子：
2.2
通讯作者：
Cheverud, JM
中科院分区：
文献类型：
--
作者：
Ehrich, TH;Vaughn, TT;Cheverud, JM
多效性是指单个基因位点影响多个表型性状。遗传位点的多效效应被认为在进化中起着重要作用，反映了表型之间的功能和发育关系。在先前的研究中，我们研究了数量性状位点（qtl）对小鼠下颌形态的多效性与下颌结构和功能的关系。通过复制我们之前的大多数qtl并增加我们的样本量，本研究加强并扩展了我们之前的结果。与我们之前的研究一样，我们发现QTL效应往往局限于发育或功能相关的性状。此外，我们还研究了多效QTL效应的差异显性模式。当单个基因座的显性模式在性状之间发生变化时，就会出现差异显性。我们发现，多变量显性是一种普遍而实质性的现象，并且可能为自然种群中杂合性的持久性提供潜在的解释。(C) 2003 Wiley-Liss, Inc。
Pleiotropy refers to a single genetic locus that affects more than one phenotypic trait. Pleiotropic effects of genetic loci are thought to play an important role in evolution, reflecting functional and developmental relationships among phenotypes. In a previous study, we examined pleiotropic effects displayed by quantitative trait loci (QTLs) on murine mandibular morphology in relation to mandibular structure and function. In replicating most of our previous QTLs and increasing our sample size, this study strengthens and extends our earlier results. As in our previous study, we find that QTL effects tend to be restricted to developmentally or functionally related traits. In addition, we examine patterns of differential dominance for pleiotropic QTL effects. Differential dominance occurs when dominance patterns for a single locus vary among traits. We find that multivariate overdominance is a common and substantial phenomenon, and may potentially provide an explanation for the persistence of heterozygosity in natural populations. (C) 2003 Wiley-Liss, Inc.