Effective Solitary Hyperthermia Treatment of Malignant Glioma Using Stick Type CMC-magnetite. In vivo Study
Effective Solitary Hyperthermia Treatment of Malignant Glioma Using Stick Type CMC-magnetite. In vivo Study
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DOI：
10.1023/a:1015080808031
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发表时间：
2004
影响因子：
3.9
通讯作者：
T. Ohno;T. Wakabayashi;A. Takemura;J. Yoshida;A. Ito;M. Shinkai;H. Honda;Takeshi Kobayashi
中科院分区：
文献类型：
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作者：
T. Ohno;T. Wakabayashi;A. Takemura;J. Yoshida;A. Ito;M. Shinkai;H. Honda;Takeshi Kobayashi
恶性胶质瘤的各种热疗因其发热作用不完全和严格的脑降温作用而受到抑制。本文报道了一种新研制的棒状羧甲基纤维素（CMC）-磁铁矿热疗剂对恶性胶质瘤的治疗效果。将含有磁铁矿颗粒的棒状CMC-磁铁矿立体定向插入大鼠脑T-9胶质瘤中，并将大鼠暴露于交变磁场（AMF）。AMF频率为88.9 kHz，Oe为380 Oe，每天30 min。将大鼠分为三组：三次AMF应用（I组），一次AMF应用（II组）和不应用但仅注射CMC-磁铁矿（对照组）。结果，这三组的平均存活天数为44.2±10.9天（组I）、17.0±1.5天（组II）和14.4±1.5天（对照组）。本研究表明，对恶性胶质瘤有明显的攻击作用，并能显著延长大鼠的生存期。在三次AMF应用后，磁铁矿颗粒扩散通过肿瘤也是一个特征性特征。这一特点可能是本研究中脑胶质瘤热效应较大的主要原因之一。这种热疗方法可能是治疗恶性胶质瘤的一种有用的策略。
Various kinds of hyperthermic treatment for malignant glioma had been inhibited due to both their incomplete feverish action and strict cooling effect of the brain. The author shows an effective results of hyperthermia for the treatment of malignant glioma in anin vivostudy using stick type carboxymethylcellulose (CMC)-magnetite, a newly manufactured magnetite-product. A stick type CMC-magnetite, containing magnetite particles, was inserted into the T-9 glioma in the rat brain stereotactically, and the rats were exposed to an alternative magnetic field (AMF). The application time of AMF, which measured 88.9 kHz and 380 Oe, was 30 min a day. The rats were divided into three groups: three AMF applications (group I), one AMF application (group II) and no application but only injection of CMC-magnetite (control). As a result, the mean survival in days of these three groups measured 44.2±10.9 (group I), 17.0±1.5 (group II) and 14.4±1.5 (control). This investigation showed both significant effectiveness in attacking malignant glioma and significant prolonging of the survival time in rats. It is also a characteristic feature of the magnetite particles to spread through the tumor diffusely after three applications of AMF. This feature seemed to be one of the main factors that caused greater hyperthermic effect on glioma in this study. This method of hyperthermic treatment could be a useful strategy in the treatment of malignant glioma.