Surrogate Estimates of Insulin Sensitivity in Obese Youth along the Spectrum of Glucose Tolerance from Normal to Prediabetes to Diabetes
Surrogate Estimates of Insulin Sensitivity in Obese Youth along the Spectrum of Glucose Tolerance from Normal to Prediabetes to Diabetes
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DOI：
10.1210/jc.2010-2813
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发表时间：
2011-07-01
影响因子：
5.8
通讯作者：
Arslanian, Silva
中科院分区：
文献类型：
--
作者：
George, Lindsey;Bacha, Fida;Arslanian, Silva
内容：在儿童肥胖的流行病学研究中，需要简单可靠的胰岛素敏感性替代估计，因为金标准，高胰岛素-正葡萄糖钳夹，在大规模上是不可行的。目的：在糖耐量正常、糖尿病前期、肥胖青少年中，研究空腹和口服葡萄糖耐量试验（OGTT）得出的胰岛素敏感性替代指标与高胰岛素-正葡萄糖钳夹试验的相关性，患者和设计：共188名超重/肥胖青少年（10至20岁），
Context: In epidemiological studies of childhood obesity, simple and reliable surrogate estimates of insulin sensitivity are needed because the gold standard, the hyperinsulinemic-euglycemic clamp, is not feasible on a large scale.Objective: To examine the correlation of fasting and oral glucose tolerance test (OGTT)-derived surrogate indices of insulin sensitivity with the hyperinsulinemic-euglycemic clamp in obese adolescents with normal glucose tolerance, prediabetes, and diabetes.Patients and Design: A total of 188 overweight/obese adolescents (10 to