Mechanisms of impairment of interferon production by SARS-CoV-2.
Mechanisms of impairment of interferon production by SARS-CoV-2.
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DOI：
10.1042/bst20221037
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发表时间：
2023-06-28
影响因子：
3.9
通讯作者：
中科院分区：
文献类型：
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作者：
干扰素（IFN）是对病毒感染的细胞先天免疫应答的关键组分。严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）具有显著抑制宿主IFN产生的能力，有利于病毒的复制和传播。迄今为止，在28种已知的病毒编码蛋白中，已经发现16种在从检测和信号传导到细胞抗病毒应答组分的表达的转录和转录后调节的各种水平上损害宿主的先天免疫系统。此外，有证据表明，病毒基因组编码非蛋白编码microRNA样元件，也可以靶向IFN刺激的基因。在这篇简短的综述中，我们总结了目前的知识状态的因素和机制，SARS-CoV-2损害IFN的生产，从而抑制宿主的先天性抗病毒免疫反应。
Interferons (IFNs) are crucial components of the cellular innate immune response to viral infections. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has shown a remarkable capacity to suppress the host IFN production to benefit viral replication and spread. Thus far, of the 28 known virus-encoded proteins, 16 have been found to impair the host's innate immune system at various levels ranging from detection and signaling to transcriptional and post-transcriptional regulation of expression of the components of the cellular antiviral response. Additionally, there is evidence that the viral genome encodes non-protein-coding microRNA-like elements that could also target IFN-stimulated genes. In this brief review, we summarise the current state of knowledge regarding the factors and mechanisms by which SARS-CoV-2 impairs the production of IFNs and thereby dampens the host's innate antiviral immune response.