Initial evaluation of dynamic human imaging using 18F-FRP170 as a new PET tracer for imaging hypoxia
Initial evaluation of dynamic human imaging using 18F-FRP170 as a new PET tracer for imaging hypoxia
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DOI：
10.1007/bf03033987
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发表时间：
2007-02-01
影响因子：
2.6
通讯作者：
Yamada, Shogo
中科院分区：
文献类型：
--
作者：
Kaneta, Tomohiro;Takai, Yoshihiro;Yamada, Shogo
F-18-FRP170, 1-（2-氟-1-[羟甲基]乙氧基）甲基-2-硝基咪唑，是一种新型的正电子发射断层缺氧显像剂。该化合物是由f -18标记的RP170合成的，是一种新的亲水性2-硝基咪唑类似物。在本研究中，我们分析了健康志愿者的动态全身成像和3例肺癌患者的动态肿瘤成像。方法：选取4名健康男性志愿者和3名肺癌患者作为研究对象。志愿者在注射F-18-FRP170后进行约90分钟的动态全身扫描，而肺癌患者则进行约60或120分钟的动态肿瘤成像。数据以标准化摄取值（SU-V）表示。在每个器官或肿瘤的图像上放置感兴趣的区域以生成时间- suv曲线。结果：一系列动态全身扫描显示F-18-FRP170在肝脏清除后迅速从肾脏清除。在横膈膜上方观察到非常低的生理摄取。注射后早期可以清晰地观察到肺癌病灶内F-18-FRP170的摄取情况。注射后30 min左右肿瘤SUV、肿瘤/血比、肿瘤/肌比变化较小。结论：使用F-18-FRP170进行动态成像显示肾内快速消除，表明该显像剂具有较高的亲水性。膈肌以上的背景活性很低，肺癌患者在注射后早期肿瘤明显摄取F-18-FRP170。
F-18-FRP170, 1-(2-fluoro-1-[hydroxymethyl]ethoxy)methyl-2-nitroimidazole, is a new hypoxia imaging agent for positron emission tomography. This compound was synthesized by F-18-labeling of RP170, which was developed as a new hydrophilic 2-nitroimidazole analog. In the present study, we analyzed dynamic whole-body imaging in healthy volunteers and dynamic tumor imaging in three patients with lung cancer. Methods: Four healthy male volunteers and three lung cancer patients were enrolled in this study. Volunteers underwent dynamic whole-body scans just after injection of F-18-FRP170 for about 90 min, while the lung cancer patients underwent dynamic tumor imaging for about 60 or 120 min. Data are expressed as standardized uptake values (SU-V). Regions of interest were placed over images of each organ or tumor to generate time-SUV curves. Results: The series of dynamic whole-body scans showed rapid elimination of F-18-FRP170 from the kidneys following elimination from the liver. Very low physiological uptake was observed above the diaphragm. F-18-FRP170 uptake in the lung cancer lesion could be visualized clearly from early after injection. The changes of tumor SUV, tumor/blood ratio, or tumor/muscle ratio about 30 min after injection or later were small. Conclusions: Dynamic imaging using F-18-FRP170 demonstrated rapid elimination from the kidney, suggesting the high hydrophilicity of this imaging agent. The background activity above the diaphragm was very low, and patients with lung cancer showed clear tumor uptake of F-18-FRP170 early after injection.