Phage–host interactions during pseudolysogeny
Phage–host interactions during pseudolysogeny
复制标题
假溶原过程中噬菌体与宿主的相互作用
DOI：
--
复制
发表时间：
2013
期刊：
影响因子：
--
通讯作者：
A. Aertsen
中科院分区：
文献类型：
--
作者：
William Cenens;Angella Makumi;M. T. Mebrhatu;R. Lavigne;A. Aertsen
虽然噬菌体感染的研究有着悠久的历史，并催化了我们目前对细菌遗传学，分子生物学，进化和生态学的理解，但微生物学家似乎才刚刚开始探索噬菌体-宿主相互作用的复杂性。在Cenens等人最近的手稿中，我们发现了鼠伤寒沙门氏菌-噬菌体P22模型系统中假溶原性发育的分子和遗传支持。更具体地说，我们观察到存在的噬菌体载体细胞窝藏的附加型P22元件，分离不对称的后续分裂。此外，新发现的P22 ORFan蛋白（Pid）能够去抑制宿主的代谢操纵子（dgo）被证明在这些噬菌体载体细胞中特异性表达。在本附录中，我们扩大了我们的观点，关于假溶血及其对细菌和噬菌体生物学的影响。
Although the study of phage infection has a long history and catalyzed much of our current understanding in bacterial genetics, molecular biology, evolution and ecology, it seems that microbiologists have only just begun to explore the intricacy of phage–host interactions. In a recent manuscript by Cenens et al. we found molecular and genetic support for pseudolysogenic development in the Salmonella Typhimurium–phage P22 model system. More specifically, we observed the existence of phage carrier cells harboring an episomal P22 element that segregated asymmetrically upon subsequent divisions. Moreover, a newly discovered P22 ORFan protein (Pid) able to derepress a metabolic operon of the host (dgo) proved to be specifically expressed in these phage carrier cells. In this addendum we expand on our view regarding pseudolysogeny and its effects on bacterial and phage biology.