GLM-beamformer method demonstrates stationary field, alpha ERD and gamma ERS co-localisation with fMRI BOLD response in visual cortex
GLM-beamformer method demonstrates stationary field, alpha ERD and gamma ERS co-localisation with fMRI BOLD response in visual cortex
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DOI：
10.1016/j.neuroimage.2005.01.050
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发表时间：
2005-05-15
期刊：
影响因子：
5.7
通讯作者：
Morris, PG
中科院分区：
文献类型：
--
作者：
Brookes, MJ;Gibson, AM;Morris, PG
最近，我们引入了一种新的“GLM波束形成器”技术，用于MEG分析，可以精确定位锁相和非锁相神经磁效应，并将其表示为统计参数图（SPM）。这提供了一个有用的框架，比较全方位的脑磁图反应与功能磁共振成像BOLD结果。本文报道了一个“原理证明”的研究，使用一个简单的视觉范例（静态棋盘）。这五名受试者分别接受了MEG和fMRI检查。我们证明，第一次，持续（DC）领域的存在下，在视觉皮层，其共同定位与视觉BOLD响应。GLM波束形成器的分析方法也被用来研究主要的非锁相振荡效应：在阿尔法手（8-13 Hz）和事件相关的同步（ERS）在伽马波段（55-70 Hz）的事件相关的去同步（ERD）。我们显示，使用SPM和虚拟电极轨迹，这些影响的时空协方差与视觉BOLD响应。MEG和fMRI数据集之间的比较通常集中在BOLD反应和瞬态诱发反应之间的关系。在这里，我们表明，固定场和振荡功率的变化也是重要的贡献者BOLD响应，并应包括在未来的研究神经元激活和血流动力学反应之间的关系。(c)2005年爱思唯尔公司All rights reserved.
Recently, we introduced a new 'GLM-beamformer' technique for MEG analysis that enables accurate localisation of both phase-locked and non-phase-locked neuromagnetic effects, and their representation as statistical parametric maps (SPMs). This provides a useful framework for comparison of the full range of MEG responses with fMRI BOLD results. This paper reports a 'proof of principle' study using a simple visual paradigm (static checkerboard). The five subjects each underwent both MEG and fMRI paradigms. We demonstrate, for the first time, the presence of a sustained (DC) field in the visual cortex, and its co-localisation with the visual BOLD response. The GLM-beamformer analysis method is also used to investigate the main non-phase-locked oscillatory effects: an event-related desynchronisation (ERD) in the alpha hand (8-13 Hz) and an event-related synchronisation (ERS) in the gamma band (55-70 Hz). We show, using SPMs and virtual electrode traces, the spatio-temporal covariance of these effects with the visual BOLD response. Comparisons between MEG and fMRI data sets generally focus on the relationship between the BOLD response and the transient evoked response. Here, we show that the stationary field and changes in oscillatory power are also important contributors to the BOLD response, and should be included in future studies on the relationship between neuronal activation and the haemodynamic response. (c) 2005 Elsevier Inc. All rights reserved.