ATP synthesis and storage
ATP synthesis and storage
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DOI：
10.1007/s11302-012-9305-8
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发表时间：
2012-09-01
影响因子：
3.5
通讯作者：
Pinton, Paolo
中科院分区：
文献类型：
--
作者：
Bonora, Massimo;Patergnani, Simone;Pinton, Paolo
自1929年发现ATP是肌肉收缩的底物以来，关于这种嘌呤核苷酸的知识已经大大扩展。细胞代谢的许多方面都围绕着ATP的产生和消耗。重要的是要了解有氧和无氧生活中葡萄糖和氧消耗的概念，并将生物能量学与细胞内发生的大量反应联系起来。ATP被普遍认为是能量交换因子，它连接了血管紧张素Ⅱ和血管紧张素Ⅱ，但也促进了运动性收缩、磷酸化和主动运输等过程。它也是嘌呤能信号机制中的信号分子。在这篇综述中，我们将讨论与ADP磷酸化相关的ATP产生的所有主要机制，以及在应激条件下这些机制的调节和与钙信号事件的联系。最近的进展，ATP存储和嘌呤信号的特殊意义也将进行审查。
Since 1929, when it was discovered that ATP is a substrate for muscle contraction, the knowledge about this purine nucleotide has been greatly expanded. Many aspects of cell metabolism revolve around ATP production and consumption. It is important to understand the concepts of glucose and oxygen consumption in aerobic and anaerobic life and to link bioenergetics with the vast amount of reactions occurring within cells. ATP is universally seen as the energy exchange factor that connects anabolism and catabolism but also fuels processes such as motile contraction, phosphorylations, and active transport. It is also a signalling molecule in the purinergic signalling mechanisms. In this review, we will discuss all the main mechanisms of ATP production linked to ADP phosphorylation as well the regulation of these mechanisms during stress conditions and in connection with calcium signalling events. Recent advances regarding ATP storage and its special significance for purinergic signalling will also be reviewed.