Pleiotrophin as a potential biomarker in breast cancer patients
Pleiotrophin as a potential biomarker in breast cancer patients
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多效素作为乳腺癌患者的潜在生物标志物
DOI：
10.1016/j.cca.2016.12.030
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发表时间：
2017-03-01
影响因子：
5
通讯作者：
Nan, Kejun
中科院分区：
文献类型：
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作者：
Ma, Jiequn;Kong, Ying;Nan, Kejun
背景：多效生长因子（PTN）是一种多功能生长因子，在许多肿瘤中表达上调。据报道，PIN在几种细胞过程的调节中起重要作用。为探讨PTN作为乳腺癌（BC）肿瘤标志物的临床意义，采用酶联免疫吸附法（ELISA）检测105例BC患者和40例健康志愿者血清PTN水平。此外，PTN的表达在80 BC组织中的巢式病例对照study.Results：血清PIN水平升高，BC患者与健康对照组相比。受试者工作特征（ROC）曲线下面积为0.878（95%CI：0.824-0.932）。PTN的敏感性上级于CEA和CA 15 -3。高血清PTN水平与TNM分期、组织学分级和远处转移相关。此外，手术治疗后血清FUN水平显著降低。在BC组织中，PTN表达在BC组织中相对于配对的癌旁组织显著更高。多因素Logistic回归分析显示组织FM表达是乳腺癌的预后因素。结论：PTN可作为乳腺癌的潜在生物标志物。(C)2016由Elsevier B. V.出版
Background: Pleiotrophin (PTN), a multifunctional growth factor, is up-regulated in many tumors. PIN is reported to play an important role in the regulation of several cellular processes. The objective of this study is to evaluate the clinical significance of PTN as a tumor marker in breast cancer (BC).Methods: Serum PTN levels were detected in 105 BC patients and 40 healthy volunteers using ELISA. In addition, PTN expression was examined in 80 BC tissues in a nested case-control study by immunohistochemistry.Results: Serum PIN levels were elevated in BC patients compared to healthy controls. Area under receiver operating characteristic (ROC) curve was 0.878 (95% CI: 0.824-0.932). The sensitivity of serum PTN was superior to CEA and CA15-3. High serum PTN levels were associated with TNM stage, histology grade, and distant metastasis. Moreover, serum FUN levels decreased significantly after surgical treatment. In BC tissues, PTN expression was significantly higher in BC tissues relative to paired paracancerous tissues. Tissue FM expression proved to be a prognostic factor for breast cancer according to multivariable logistic regression analysis.Conclusion: PTN could be considered as a potential biomarker for the presence of breast cancer. (C) 2016 Published by Elsevier B.V.