USE OF BOTULINUM TOXIN TYPE-F INJECTIONS TO TREAT TORTICOLLIS IN PATIENTS WITH IMMUNITY TO BOTULINUM TOXIN TYPE-A
USE OF BOTULINUM TOXIN TYPE-F INJECTIONS TO TREAT TORTICOLLIS IN PATIENTS WITH IMMUNITY TO BOTULINUM TOXIN TYPE-A
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DOI：
10.1002/mds.870080411
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发表时间：
1993-10-01
影响因子：
8.6
通讯作者：
FAHN, S
中科院分区：
文献类型：
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作者：
GREENE, PE;FAHN, S
15名斜颈患者反复注射A型肉毒杆菌毒素（Botox A）后产生了毒素抗体。这导致13名注射肉毒杆菌毒素A后有所改善的患者失去了益处，并且所有15名患者在注射后都没有出现肌肉萎缩。然后，患者在注射肉毒杆菌毒素A的同一肌肉中注射F型肉毒杆菌毒素（肉毒杆菌毒素F）。15名患者中有10名在注射肉毒杆菌F后有所改善。包括12名A型毒素治疗后病情好转的患者中的9名。9名疼痛患者中有6名在注射肉毒杆菌F后疼痛有所改善。患者报告F型和A型毒素的改善相似，但A型毒素的获益持续时间约为3个月，F型毒素约为1个月。肉毒杆菌F是一种有效的治疗斜颈的患者谁是免疫肉毒杆菌A。然而，F型毒素的有效性受到短时间益处的限制。
Fifteen patients with torticollis who had been treated with repeated injections of botulinum toxin type A (botox A) developed antibodies to the toxin. This resulted in loss of benefit in the 13 patients who had improved with botox A injections and failure to develop muscle atrophy after injection in all 15 patients. Patients were then injected with botulinum toxin type F (botox F) in the same muscles that had been injected with botox A. Ten of the 15 improved after botox F injections. including 9 of the 12 patients who had improved with type A toxin. Six of 9 patients with pain had improvement in pain after botox F injections. Patients reported similar improvement with type F and type A toxins, but duration of benefit was approximately 3 months with type A and approximately 1 month with type F. Botox F is an effective treatment for torticollis in patients who are immune to botox A. The usefulness of type F toxin, however, is limited by short duration of benefit.