EFFECTS OF METHYLENE-CHLORIDE, TRICHLOROETHANE, TRICHLOROETHYLENE, TETRACHLOROETHYLENE AND TOLUENE ON THE DEVELOPMENT OF CHICK-EMBRYOS
EFFECTS OF METHYLENE-CHLORIDE, TRICHLOROETHANE, TRICHLOROETHYLENE, TETRACHLOROETHYLENE AND TOLUENE ON THE DEVELOPMENT OF CHICK-EMBRYOS
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DOI：
10.1016/0300-483x(79)90037-4
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发表时间：
1979-01-01
期刊：
影响因子：
4.5
通讯作者：
VAINIO, H
中科院分区：
文献类型：
--
作者：
ELOVAARA, E;HEMMINKI, K;VAINIO, H
在孵化第2、3和6天时，将甲苯和5种广泛工业用途的脂肪族氯化烃注入受精鸡蛋的空气空间中。以孵化14天后的存活率和死亡率来评估胚胎毒性，并记录胚胎的重量和长度。三氯乙烯和三氯乙烷的近似LD50值在50-100μmol/蛋之间变化，而甲苯、四氯乙烯和二氯甲烷的LD50值超过100μmol/蛋。用5-100μmol/蛋的剂量产生各种肉眼可见的畸形。受试化合物的致畸潜力按以下顺序降低：1,1,1-三氯乙烷>三氯乙烯>二氯甲烷、四氯乙烯、1,1,2-三氯乙烷>甲苯>橄榄油对照。
Toluene and 5 aliphatic chlorinated hydrocarbons of wide industrial use were injected into the air space of fertilized chicken eggs at 2, 3 and 6 days of incubation. The embryotoxicity was evaluated as survival and death incidences after 14 days of incubation, and also the weights and lengths of the embryos were recorded. The approximate LD50 value for trichloroethylene and trichloroethanes varied from 50-100 .mu.mol/egg while for toluene, tetrachloroethylene and methylene chloride it was over 100 .mu.mol/egg. Macroscopic malformations of various kinds were produced with doses of 5-100 .mu.mol/egg. The teratogenic potential of the tested compounds decreased in the following order: 1,1,1-trichloroethane > trichloroethylene > methylene chloride, tetrachloroethylene, 1,1,2-trichloroethane > toluene > olive oil control.