The efficacy of cognitive rehabilitation with RehaCom programme in schizophrenia patients. The role of selected genetic polymorphisms in successful cognitive rehabilitation.
The efficacy of cognitive rehabilitation with RehaCom programme in schizophrenia patients. The role of selected genetic polymorphisms in successful cognitive rehabilitation.
复制标题
RehaCom 计划对精神分裂症患者认知康复的疗效。
DOI：
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发表时间：
2013
影响因子：
1.7
通讯作者：
B. Mroczek
中科院分区：
文献类型：
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作者：
M. Mak;J. Samochowiec;P. Tybura;P. Bieńkowski;B. Karakiewicz;Liliana Zaremba Pechmann;B. Mroczek
介绍
精神分裂症患者存在认知功能障碍，认知功能障碍被认为是精神分裂症易感的内表型标志之一。目前，精神分裂症可以作为一种具有遗传背景的神经退行性和神经发育性疾病来治疗。
目的
神经心理康复对精神分裂症认知功能障碍患者可能的积极作用的评估。另一个目的是验证假设，一些遗传多态性可以是神经心理康复成功的预后因素。
材料和方法
随机选择41名参与者和40名对照受试者。两组均诊断为偏执型精神分裂症。在实验开始和结束时用威斯康星州卡片分类测验、连线测验和Stroop测验检查认知功能。在研究组中，每个患者都接受了康复计划RehaCom的训练，而对照组没有接受这种训练。在研究的遗传部分中分析了基因COMT rs4680和BDNF rs6265。
结果
RehaCom程序似乎对诊断为精神分裂症患者的认知功能障碍的神经心理康复有用。研究小组显示，培训方案略有改进。神经心理学测试中获得的参数分析显示，两组都略有改善。目前，基因多态性的分析不能被视为神经心理康复成功的预后因素，因为统计分析显示很少有依赖性，几乎没有统计学意义。
结论
认知康复可中度改善认知功能。
INTRODUCTION
Schizophrenic patients present cognitive dysfunctions which are regarded to be one of endophenotypical markers predisposing to schizophrenia. Currently, schizophrenia can be treated as a neurodegenerative and neurodeveloping disease with genetic background.
OBJECTIVE
Assessment of the possible positive effect of neuropsychological rehabilitation in schizophrenia, in patients presenting cognitive dysfunctions. An additional aim was to verify the hypothesis that some genetic polymorphisms can be a prognostic factor for success in neuropsychological rehabilitation.
MATERIAL AND METHODS
41 participants and 40 control subjects were randomly selected. Both groups had the diagnosis of paranoid schizophrenia. Cognitive functions were checked with the Wisconsin Card Sorting Test, Trail Making Test, and Stroop Test at the beginning and end of the experiment. In the research group, each patient trained with the rehabilitation programme RehaCom, whereas the control group did not receive such training. Genes COMT rs4680 and BDNF rs6265 were analysed in the genetic part of study.
RESULTS
RehaCom procedures appear to be useful in the neuropsychological rehabilitation of cognitive dysfunctions in patients diagnosed with schizophrenia. The research group showed a moderate improvement in the training programmes. Analysis of parameters obtained in the neuropsychological tests showed a slight improvement in both groups. At the present time, analysis of the polymorphisms of genes cannot be treated as a prognostic factor for the success of neuropsychological rehabilitation because statistical analyses showed few dependences with little statistical significance.
CONCLUSIONS
Cognitive rehabilitation produces moderate improvement in cognitive functioning.
影响因子：
17.7
作者：
Fuller, R;Nopoulos, P;Andreasen, NC
通讯作者：
Andreasen, NC