Pattern recognition receptors in Drosophila immune responses
Pattern recognition receptors in Drosophila immune responses
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DOI：
10.1016/j.dci.2019.103468
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发表时间：
2020-01-01
影响因子：
2.9
通讯作者：
Yu, Xiao-Qiang
中科院分区：
文献类型：
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作者：
Lu, Yuzhen;Su, Fanghua;Yu, Xiao-Qiang
缺乏适应性免疫系统的昆虫，已经发展出复杂的先天免疫系统，包括体液免疫和细胞免疫反应，以防御入侵的微生物。微生物的非自我识别是先天免疫系统的前线。模式识别受体（PRRs）识别微生物中存在的保守的病原体相关分子模式（PAMPs），如脂多糖（LPS）、肽聚糖（PGN）、脂质胆酸（LTA）和β - 1,3 -葡聚糖，并诱导先天免疫反应。本文综述了黑胃果蝇模型生物PRRs的结构、分类及其在先天免疫中的作用，主要包括肽聚糖识别蛋白（PGRPs）、革兰氏阴性细菌结合蛋白（gnbp）、清道夫受体（SRs）、含硫酯蛋白（TEPs）和凝集素。
Insects, which lack the adaptive immune system, have developed sophisticated innate immune system consisting of humoral and cellular immune responses to defend against invading microorganisms. Non-self recognition of microbes is the front line of the innate immune system. Repertoires of pattern recognition receptors (PRRs) recognize the conserved pathogen-associated molecular patterns (PAMPs) present in microbes, such as lipopolysaccharide (LPS), peptidoglycan (PGN), lipoteichoic acid (LTA) and beta-1, 3-glucans, and induce innate immune responses. In this review, we summarize current knowledge of the structure, classification and roles of PRRs in innate immunity of the model organism Drosophila melanogaster, focusing mainly on the peptidoglycan recognition proteins (PGRPs), Gram-negative bacteria-binding proteins (GNBPs), scavenger receptors (SRs), thioester-containing proteins (TEPs), and lectins.