Anthraquinone Derivatives from a Marine-Derived Fungus Sporendonema casei HDN16-802
Anthraquinone Derivatives from a Marine-Derived Fungus Sporendonema casei HDN16-802
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来自海洋源真菌干酪孢子菌的蒽醌衍生物 HDN16-802
DOI：
10.3390/md17060334
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发表时间：
2019-06-01
期刊：
影响因子：
5.4
通讯作者：
Zhang, Guojian
中科院分区：
文献类型：
--
作者：
Ge, Xueping;Sun, Chunxiao;Zhang, Guojian
从海洋来源的干酪孢子藻的培养中分离得到5个新的蒽醌类化合物，Axarthrols D-H(1-5)和两个已知的类似物(6-7)。通过核磁共振、HRESIMS和圆二色谱技术确定了它们的结构，包括绝对构型。其中，化合物4代表具有氯原子的第二个分离的蒽醌衍生物，与化合物6一起，是首次报道的具有抗凝血活性的蒽醌衍生物。化合物1和3具有细胞毒活性，IC50值在4.5~22.9 mU M之间，化合物1、3~4和6~7具有良好的抗菌活性，其MIC值在12.5~200 mU M之间。化合物7的抗结核活性为首次发现。
Five new anthraquinone derivatives, auxarthrols D-H (1-5), along with two known analogues (6-7), were obtained from the culture of the marine-derived fungus Sporendonema casei. Their structures, including absolute configurations, were established on the basis of NMR, HRESIMS, and circular dichroism (CD) spectroscopic techniques. Among them, compound 4 represents the second isolated anthraquinone derivative with a chlorine atom, which, with compound 6, are the first reported anthraquinone derivatives with anticoagulant activity. Compounds 1 and 3 showed cytotoxic activities with IC50 values from 4.5 mu M to 22.9 mu M, while compounds 1, 3-4, and 6-7 showed promising antibacterial activities with MIC values from 12.5 mu M to 200 mu M. In addition, compound 7 was discovered to display potential antitubercular activity for the first time.