Complete Genome Sequence of the Neonatal-Meningitis-Associated Escherichia coli Strain CE10

Complete Genome Sequence of the Neonatal-Meningitis-Associated Escherichia coli Strain CE10
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DOI:
10.1128/jb.06284-11
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发表时间:
2011-12-01
影响因子:
3.2
通讯作者:
Jin, Qi
Jin, Qi
中科院分区:
生物学3区
文献类型:
--
作者:
Lu, Shuting;Zhang, Xiaobing;Jin, Qi

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新生儿细菌性脑膜炎仍然是全世界死亡和发病的重要原因。含有 K1 荚膜多糖的大肠杆菌是引起新生儿脑膜炎的最常见革兰氏阴性病原体。在这里,我们展示了新生儿脑膜炎相关大肠杆菌菌株 CE10 的完整基因组序列,这是一种具有功能性 III 型分泌系统的独特 K1 菌株。基因组的功能分析应该增强我们对新生儿大肠杆菌 K1 脑膜炎发病机制的了解。
Neonatal bacterial meningitis continues to be an important cause of mortality and morbidity worldwide. Escherichia coli possessing the K1 capsular polysaccharide is the most common Gram-negative pathogen causing neonatal meningitis. Here we present the complete genome sequence of neonatal meningitis-associated E. coli strain CE10, a unique K1 strain with a functional type III secretion system. Functional analysis of the genome should enhance our knowledge of the pathogenesis of neonatal E. coli K1 meningitis.