Prefrontal cortex and hippocampus subserve different components of working memory in rats.
Prefrontal cortex and hippocampus subserve different components of working memory in rats.
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前额叶皮层和海马体促进大鼠工作记忆的不同组成部分。
DOI：
10.1101/lm.850808
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Kim,JeansokJ
中科院分区：
文献类型：
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作者：
Yoon,Taejib;Okada,Jeffrey;Jung,MinW;Kim,JeansokJ
内侧前额叶皮层（mPFC）和海马体都与啮齿动物的工作记忆任务有关。具体来说，假设mPFC主要参与从亚秒到几秒的信息的临时存储和处理，而海马功能随着工作记忆需求扩展到更长的时间尺度而变得更加关键。虽然这些结构可能以一种暂时可分离的方式参与，但它们在工作记忆的“信息内容”中的贡献程度仍不清楚。为了研究这一问题，在大鼠执行延迟交替任务（DAT）之前，通过靶向输注gaba受体激动剂muscimol，使其mPFC和背侧海马体（dHPC）暂时失活，采用自动数字8迷宫，要求动物在延迟3、30和60秒后做出交替手臂选择反应，以获得水奖励。我们报告说，在所有测试的延迟间隔中，mPFC或dHPC的失活都显着减少了数据。然而，在行为影响方面存在关键的定性差异。具体而言，mPFC失活选择性地损害了工作记忆（即手臂选择准确性），而不改变参考记忆（即迷宫任务规则）和手臂选择反应延迟。相反，dHPC失活增加了参考记忆错误和手臂选择反应延迟。此外，dHPC而非mPFC失活增加了连续工作记忆错误的发生率。这些结果表明，虽然mPFC和海马体都必然参与到DAT中，但它们似乎处理与记忆任务相关的不同信息成分。
Both the medial prefrontal cortex (mPFC) and hippocampus are implicated in working memory tasks in rodents. Specifically, it has been hypothesized that the mPFC is primarily engaged in the temporary storage and processing of information lasting from a subsecond to several seconds, while the hippocampal function becomes more critical as the working memory demand extends into longer temporal scales. Although these structures may be engaged in a temporally separable manner, the extent of their contributions in the “informational content” of working memory remains unclear. To investigate this issue, the mPFC and dorsal hippocampus (dHPC) were temporarily inactivated via targeted infusions of the GABAAreceptor agonist muscimol in rats prior to their performance on a delayed alternation task (DAT), employing an automated figure-eight maze that required the animals to make alternating arm choice responses after 3-, 30-, and 60-sec delays for water reward. We report that inactivation of either the mPFC or dHPC significantly reduced DAT at all delay intervals tested. However, there were key qualitative differences in the behavioral effects. Specifically, mPFC inactivation selectively impaired working memory (i.e., arm choice accuracy) without altering reference memory (i.e., the maze task rule) and arm choice response latencies. In contrast, dHPC inactivation increased both reference memory errors and arm choice response latencies. Moreover, dHPC, but not mPFC, inactivation increased the incidence of successive working memory errors. These results suggest that while both the mPFC and hippocampus are necessarily involved in DAT, they seem to process different informational components associated with the memory task.