Effects of brain stem lesions on 10-Hz and 2- to 6-Hz rhythms in sympathetic nerve discharge.
Effects of brain stem lesions on 10-Hz and 2- to 6-Hz rhythms in sympathetic nerve discharge.
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脑干病变对交感神经放电中 10 Hz 和 2 至 6 Hz 节律的影响。
DOI：
10.1152/ajpregu.1992.262.6.r1015
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Gebber,GL
中科院分区：
文献类型：
--
作者：
Zhong,S;Barman,SM;Gebber,GL
本实验研究了损毁或切断脑干对压力感受器去麻醉去大脑猫交感神经放电(SND)中10-HZ和2-6-HZ节律的影响。结果表明，这两种节律在一定程度上取决于不同的脑干区域。通过消融延髓头端腹外侧核(RVLM)、延髓中缝复合体或桥臂旁和Kolliker-Fuse复合体(PB/KF)或桥延髓边缘横断术消除10-HZ节律。除RVLM病变外，这些手术并未扰乱SND的2-6赫兹节律。事实上，损毁中缝或PB/KF可增加SND在低于6 Hz的频率下的功率。SND的总功率不受中缝或PB/KF病变的影响，但平均动脉压显著降低。从RVLM(26个部位中有11个)和中缝(20个部位中有10个)记录到的场电位与SND的10-Hz节律相关，进一步支持了这些区域在产生或传递这种节律到交感神经中的作用。相反，从PB/KF记录到的场电位与SND的10-HZ节律没有相关性。因此，这一区域可能为位于脑干其他部位的10赫兹发生器提供一种紧张性驱动。
We studied the effects of brain stem lesions or transection on the 10-Hz and 2- to 6-Hz rhythms in sympathetic nerve discharge (SND) in baroreceptor-denervated unanesthetized decerebrate cats. The results indicate that these two rhythms depend in part on different brain stem regions. The 10-Hz rhythm was eliminated by ablation of the rostral ventrolateral medulla (RVLM), medullary raphe complex, or pontine parabrachial and Kolliker-Fuse complex (PB/KF) or by pontomedullary border transection. Except for RVLM lesions, these procedures did not disrupt the 2- to 6-Hz rhythm in SND. In fact the power in SND at frequencies less than 6 Hz was increased by raphe or PB/KF lesions. Total power in SND was not significantly affected by raphe or PB/KF lesions, but mean arterial pressure was significantly reduced. Field potentials recorded from the RVLM (11 of 26 sites) and raphe (10 of 20 sites) were correlated to the 10-Hz rhythm in SND, further supporting a role of these areas in either generating or relaying this rhythm to sympathetic nerves. In contrast, field potentials recorded from the PB/KF were not correlated to the 10-Hz rhythm in SND. Thus this region may provide a tonic drive to the 10-Hz generator located elsewhere in the brain stem.