Moderate Physical Activity in Healthy Adults Is Associated With Cardiac Remodeling
Moderate Physical Activity in Healthy Adults Is Associated With Cardiac Remodeling
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DOI：
10.1161/circimaging.116.004712
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发表时间：
2016-08-01
影响因子：
7.5
通讯作者：
O'Regan, Declan P.
中科院分区：
文献类型：
--
作者：
Dawes, Timothy J. W.;Corden, Ben;O'Regan, Declan P.
背景：运动员的心脏质量和体积经常升高，但尚不清楚适度的体育活动是否也与健康成年人的心脏扩张和肥厚有关。方法和结果：共有1096名无心血管疾病或心肌病相关遗传变异的成年人（54%为女性，中位年龄39岁）接受了心脏磁共振成像，以确定双心室容量和功能。使用有效的活动问卷对身体活动进行评估。通过调整年龄、性别、种族和收缩压，使用多元线性回归评估心脏参数和活动之间的关系。根据标准心脏磁共振正常范围，进行逻辑回归以确定活动对受试者心脏扩张或肥厚可能性的影响。体力活动增加与左心室（LV）质量增大相关(β =0.23
Background-Cardiac mass and volumes are often elevated in athletes, but it is not known whether moderate physical activity is also associated with cardiac dilatation and hypertrophy in a healthy adult population.Methods and Results-In total, 1096 adults (54% female, median age 39 years) without cardiovascular disease or cardiomyopathy-associated genetic variants underwent cardiac magnetic resonance imaging to determine biventricular volumes and function. Physical activity was assessed using a validated activity questionnaire. The relationship between cardiac parameters and activity was assessed using multiple linear regression adjusting for age, sex, race, and systolic blood pressure. Logistic regression was performed to determine the effect of activity on the likelihood of subjects having cardiac dilatation or hypertrophy according to standard cardiac magnetic resonance normal ranges. Increasing physical activity was associated with greater left ventricular (LV) mass (beta=0.23; P