Behavioral and functional neuroimaging evidence for prefrontal dysfunction in methamphetamine-dependent subjects
Behavioral and functional neuroimaging evidence for prefrontal dysfunction in methamphetamine-dependent subjects
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DOI：
10.1016/s0893-133x(01)00334-7
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发表时间：
2002-01-01
影响因子：
7.6
通讯作者：
Schuckit, MA
中科院分区：
文献类型：
--
作者：
Paulus, MP;Hozack, NE;Schuckit, MA
兴奋剂依赖的受试者在决策方面表现出与腹内侧前额皮质病变受试者相似的功能障碍。对药物渴望、奖励关联和决策的研究表明，背外侧和眶额皮质作为兴奋剂依赖受试者的关键神经基质功能障碍。本研究通过功能性磁共振成像（fMRI）研究来确定决策功能障碍与不同前额叶区域神经激活之间的关系。本研究检验了一种行为假设，即早期持续缓解的甲基苯丙胺依赖受试者表现出决策功能障碍，这与对刺激-偶然反应选择的依赖增加一致。据推测，这些决策功能障碍是由于背外侧和腹内侧前额叶皮层中任务相关激活的差异。10名甲基苯丙胺依赖的受试者与10名年龄和教育程度相匹配的对照组进行比较，在功能磁共振成像期间执行两项预测任务和两项反应任务。获得了评估决策序列潜在策略的反应偏差、延迟和互信息测度。首先，在两项选择预测任务中，依赖甲基苯丙胺的受试者比正常对照受试者更容易受到前一结果的影响。其次，在两项预测任务中，与两项反应任务相比，甲基苯丙胺依赖受试者的背外侧前额叶皮层（ba9）激活较少，腹内侧皮层（ba10、11）未被激活。这些结果支持了兴奋剂依赖受试者在决策过程中表现出基本认知缺陷的基本假设，这与眼窝额叶和背外侧前额叶功能障碍相一致。[j] (1) (C) 2001中华医学会精神病学分会。Elsevier Science Inc.出版。
Stimulant-dependent subjects show dysfunctions in decision-making similar to those seen in subjects with ventromedial prefrontal cortex lesions. Studies of drug craving, reward association, and decision-making have implicated dysfunctions of the dorsolateral and orbitofrontal cortex as a key neural substrate in subjects with stimulant dependence. Here, a functional magnetic resonance imaging (fMRI) study was carried out to determine the relationship between decision-making dysfunction and neural activation in different prefrontal areas. This investigation tested the behavioral hypothesis that methamphetamine-dependent subjects in early sustained remission show decision-making dysfunctions that are consistent with an increased reliance on stimulus-contingent response selection. It was hypothesized that these decision-making dysfunctions are due to differences in task-related activation in the dorsolateral and ventromedial prefrontal cortex. Ten methamphetamine-dependent subjects were compared with ten age- and education-matched controls performing a two-choice prediction task and a two-choice response task during a fMRI session. Response bias, latency, and mutual information measures assessing the underlying strategies of the decision-making sequences were obtained. First, methamphetamine-dependent subjects were more influenced by the immediately preceding outcome during the two-choice prediction task relative to normal comparison subjects. Second, methamphetamine-dependent subjects activated less dorsolateral prefrontal cortex (BA 9) and failed to activate ventromedial cortex (BA 10,11) during the two-choice prediction task compared with the two-choice response task. These results support the basic hypothesis that stimulant-dependent subjects exhibit fundamental cognitive deficits during decision-making that are consistent with both orbitofrontal and dorsolateral prefrontal dysfunction. [Neuropsychopharmacology 26:53-63, 2002] () (C) 2001 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.