Stereocontrolled synthesis of 1,3-diols from enones: cooperative Lewis base-mediated intramolecular carbonyl hydrosilylations.
Stereocontrolled synthesis of 1,3-diols from enones: cooperative Lewis base-mediated intramolecular carbonyl hydrosilylations.
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从烯酮立体控制合成 1,3-二醇：协同路易斯碱介导的分子内羰基氢化硅烷化。
DOI：
10.1021/jo401293a
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
O'Neil,GregoryW
中科院分区：
文献类型：
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作者：
Medina,Casey;Carter,KyleP;Miller,Michael;Clark,TimothyB;O'Neil,GregoryW
为了进一步研究最近发现的路易斯碱介导的分子内羰基硅氢化反应，研究了β-羟基酮底物的流线型合成。该合成具有烯酮β-硼化/氧化序列，已被证明是相当普遍和高产的。这使得通过制备重要的聚酮片段来进一步研究硅氢化反应的非对映选择性成为可能。
A streamlined synthesis of β-hydroxy ketone substrates has been developed to further investigate a recently discovered cooperative Lewis base-mediated intramolecular carbonyl hydrosilylation reaction. The synthesis features an enone β-borylation/oxidation sequence that has proven to be quite general and high-yielding. This has allowed for additional investigations into the diastereoselectivity of the hydrosilylation reaction through the preparation of important polyketide fragments.