Concepts basic to pharmacokinetics.
Concepts basic to pharmacokinetics.
复制标题
药代动力学的基本概念。
DOI：
10.1016/0163-7258(81)90077-2
复制
发表时间：
1981
影响因子：
13.5
通讯作者：
T. Tozer
中科院分区：
文献类型：
--
作者：
T. Tozer
药代动力学是研究药物及其代谢产物在体内的时间过程，它是从化学动力学、生理学和生物化学的基本原理发展而来的。这些原则已经汇集在一起，并进一步发展成为现在所称的药代动力学学科。这门学科是药理学的一个组成部分;它从化学动力学借用定量工具，但严重依赖生理学，在某种程度上，生物化学来解释和预测药物及其代谢物在体内的动力学行为。药代动力学的基本概念可以根据个人的观点进行不同的定义和分类。在这个介绍中，重点是给予生理，而不是化学动力学的描述和发展的基本概念。
Pharmacokinetics, the study of the time course of drugs and their metabolites in the body, has evolved from fundamental principles of chemical kinetics, physiology, and biochemistry. These principles have been brought together and further developed into what is now referred to as the discipline of pharmacokinetics. This discipline is a component of pharmacology; it borrows quantitative tools from chemical kinetics, but leans heavily on physiology and, to some degree, biochemistry to explain and predict the kinetic behavior of drugs and their metabolites in the body. The concepts that are basic to pharmacokinetics may be defined and classified differently, depending on one's point of view. In this presentation, emphasis is given to a physiologic rather than a chemical kinetic description and development of the basic concepts.