Protein Z influences the prothrombotic phenotype in factor v Leiden patients
Protein Z influences the prothrombotic phenotype in factor v Leiden patients
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DOI：
10.1016/s0049-3848(02)00181-0
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发表时间：
2002-05-15
影响因子：
7.5
通讯作者：
Matthes, KJ
中科院分区：
文献类型：
--
作者：
Kemkes-Matthes, B;Nees, M;Matthes, KJ
蛋白Z增强蛋白Z依赖性蛋白酶抑制剂（ZPI）对Xa因子的抑制。因此，蛋白Z的减少应诱导血栓形成倾向，由于降低了ZPI的胶原活性。在因子V Leiden小鼠中，证明了蛋白Z严重减少或缺乏的促血栓形成倾向。我们在这里首次提出了人体研究，表明莱顿因子V患者中蛋白Z的减少会加剧血栓栓塞风险。(C)2002爱思唯尔科技有限公司版权所有。
Protein Z enhances the inhibition of factor Xa by protein Z-dependent protease inhibitor (ZPI). Thus, diminution of protein Z should induce prothrombotic tendency due to lowered collactor activity for ZPI. In Factor V Leiden mice, prothrombotic tendency of severe diminution or lack of protein Z was demonstrated. We here present first studies in humans, indicating that diminution of protein Z in factor V Leiden patients aggravates thromboembolic risk. (C) 2002 Elsevier Science Ltd. All rights reserved.