Fluid dynamics of the mitral valve: physiological aspects of a mathematical model.
Fluid dynamics of the mitral valve: physiological aspects of a mathematical model.
复制标题
DOI：
10.1152/ajpheart.1982.242.6.h1095
复制
发表时间：
1982-06
期刊：
影响因子：
--
通讯作者：
D. McQueen;C. Peskin;E. Yellin
中科院分区：
文献类型：
--
作者：
D. McQueen;C. Peskin;E. Yellin
本文提出了一种可用于研究流体计算方法的计算方法，该方法可用于研究具有收缩肌壁的模拟心脏左侧的计算机试验室内天然或人工二尖瓣的流体动力学。在求解了运动方程并预测了阀门的性能后，计算机以流动模式（流线）、压力轮廓图以及速度、压力、流量、张力和距离随时间的函数图的形式给出了结果。预测超声心动图和心音图也由计算机生成。将这些预测结果与动物实验结果进行比较，并应用该方法研究腱索的舒张作用、二尖瓣脱垂综合征的病理生理以及旋转盘瓣的流体动力学。我们的结果支持索在舒张期有功能作用的假设。结果还建立了二尖瓣脱垂的计算机模型，该模型可用于二尖瓣脱垂的功能研究，并表明枢轴点的位置和闭塞器的曲率对旋转盘瓣的开度角有深远的影响。这些研究说明了该方法在生理学、病理生理学和人工瓣膜设计中的应用。
This paper presents a computational method that can be used to study the fluid computational method that can be used to study the fluid dynamics of the natural or prosthetic mitral valve in a computer test chamber with contractile muscular walls that model the left side of the heart. Having solved the equations of motion and predicted the performance of the valve, the computer presents the results in terms of flow patterns (streamlines), pressure-contour plots, and graphs of velocity, pressure, flow, tension, and distance as functions of time. Predicted echocardiograms and phonocardiograms are also generated by the computer. These predictions are compared with the results of animal experiments, and the method is used to study the diastolic role of the chordae tendineae, the pathophysiology of mitral valve prolapse syndrome, and the fluid dynamics of pivoting disc valves. Our results support the hypothesis that the chordae have a functional role during diastole. The results also establish a computer model of mitral prolapse, which should be useful in functional studies of that condition, and show that the position of the pivot point and the curvature of the occluder can have a profound effect on the angle of opening of pivoting disc valves. These studies illustrate the applications of the method in physiology, pathophysiology, and prosthetic valve design.