Role of gene duplications in the adaptation of Salmonella typhimurium to growth on limiting carbon sources.
Role of gene duplications in the adaptation of Salmonella typhimurium to growth on limiting carbon sources.
复制标题
基因复制在鼠伤寒沙门氏菌适应限制碳源生长中的作用。
DOI：
10.1093/genetics/123.1.19
复制
发表时间：
1989
期刊：
影响因子：
3.3
通讯作者：
Roth,JR
中科院分区：
文献类型：
--
作者：
Sonti,RV;Roth,JR
当鼠伤寒沙门氏菌的生长受到几种碳和能量来源中的任何一种的限制时，选择含有复制的细胞。在极度饥饿的条件下，生长几乎只发生在种群中含有重复的部分。无论哪一种碳源限制了细胞的生长，重复选择具有一大块染色体重复的细胞。复制的染色体片段编码了所有这些碳源的运输系统。这种重复在碳源上生长时不被选择，因为渗透酶不包括在重复片段内。这表明，复制所带来的生长优势可能是由于限制性碳源的运输增加。单独包含透性酶并不足以解释重复的生长优势，因为没有选择包含透性酶的其他常见重复。
Duplication-containing cells are selected when growth of Salmonella typhimurium is limited by the availability of any one of several carbon and energy sources. Under conditions of extreme starvation, growth occurs almost exclusively in the duplication-containing fraction of the population. Cells with duplications of one large segment of the chromosome are repeatedly selected regardless of which of these carbon sources limits growth. The duplicated chromosomal segment encodes the transport systems for all of these carbon sources. This duplication is not selected during growth on a carbon source for which the permease is not included within the duplication segment. This suggests that the growth advantage conferred by the duplication may be due to increased transport of the limiting carbon source. Inclusion of the permease alone is not sufficient to explain the growth advantage of the duplications, since other common duplications that include the permease are not selected.